Synthesis of prostaglandins by psoriatic skin
The biosynthesis of prostaglandins (PG) in biopsies from 9 patients with psoriasis was studied. The involved as well as the uninvolved psoriatic skin showed a statistically significant decrease of the ability to synthesize PG's. In PGE1-equivalents the concentration (mean +/- S.E.M.) was 4.41 +...
Gespeichert in:
| Veröffentlicht in: | Archives for Dermatological Research 1977-01, Vol.259 (3), p.207-212 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 212 |
|---|---|
| container_issue | 3 |
| container_start_page | 207 |
| container_title | Archives for Dermatological Research |
| container_volume | 259 |
| creator | Kassis, V Weismann, K Heiligstädt, H Sondergaard, J |
| description | The biosynthesis of prostaglandins (PG) in biopsies from 9 patients with psoriasis was studied. The involved as well as the uninvolved psoriatic skin showed a statistically significant decrease of the ability to synthesize PG's. In PGE1-equivalents the concentration (mean +/- S.E.M.) was 4.41 +/- 0.48 ng/g wet weight in the psoriatic lesion, 5.41 +/- 0.64 ng/g wet weight in uninvolved psoriatic skin in the presence of exogenous arachidonic acid in the incubation medium as compared with 9.02 +/- 1.59 in normal human skin. When the skin was incubated without excess of exogenous precursor acid the activity formed was similarly significantly lower in psoriatic skin as compared with normal skin. A disturbed balance between E and F PG synthesis was not demonstrated, which might have accounted for the postulated altered intracellular ratio of cyclic AMP to cyclic GMP in psoriatic skin. |
| doi_str_mv | 10.1007/BF00561448 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF00561448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>199118</sourcerecordid><originalsourceid>FETCH-LOGICAL-c250t-d7354de8dda767551f63360210a7e377637def995b803aa85f33de27818e8e293</originalsourceid><addsrcrecordid>eNpFjztPwzAUhS3EKypdmBkyIxmuff0coaKAVIkBkNgiJ7bB0KZRHIb8ewJF6lnO8unofIScM7hiAPr6dgkgFRPCHJCCCeQUlH07JAWgAIrKqlMyz_kTpmgQHPQJOWbWMmYKQp_HdvgIOeVyG8uu3-bBva9d61Oby3osu7ztkxtSU-av1J6Ro-jWOcz_e0Zel3cviwe6erp_XNysaMMlDNRrlMIH473TSkvJokJUwBk4HVBrhdqHaK2sDaBzRkZEH7g2zAQTuMUZudztNtOh3IdYdX3auH6sGFS_0tVeeoIvdnD3XW-C36N_ivgDhOpPmw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Synthesis of prostaglandins by psoriatic skin</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kassis, V ; Weismann, K ; Heiligstädt, H ; Sondergaard, J</creator><creatorcontrib>Kassis, V ; Weismann, K ; Heiligstädt, H ; Sondergaard, J</creatorcontrib><description>The biosynthesis of prostaglandins (PG) in biopsies from 9 patients with psoriasis was studied. The involved as well as the uninvolved psoriatic skin showed a statistically significant decrease of the ability to synthesize PG's. In PGE1-equivalents the concentration (mean +/- S.E.M.) was 4.41 +/- 0.48 ng/g wet weight in the psoriatic lesion, 5.41 +/- 0.64 ng/g wet weight in uninvolved psoriatic skin in the presence of exogenous arachidonic acid in the incubation medium as compared with 9.02 +/- 1.59 in normal human skin. When the skin was incubated without excess of exogenous precursor acid the activity formed was similarly significantly lower in psoriatic skin as compared with normal skin. A disturbed balance between E and F PG synthesis was not demonstrated, which might have accounted for the postulated altered intracellular ratio of cyclic AMP to cyclic GMP in psoriatic skin.</description><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/BF00561448</identifier><identifier>PMID: 199118</identifier><language>eng</language><publisher>Germany</publisher><subject>Adenosine Monophosphate - metabolism ; Arachidonic Acids - metabolism ; Cyclic AMP - metabolism ; Humans ; Prostaglandins - biosynthesis ; Psoriasis - metabolism ; Skin - metabolism</subject><ispartof>Archives for Dermatological Research, 1977-01, Vol.259 (3), p.207-212</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c250t-d7354de8dda767551f63360210a7e377637def995b803aa85f33de27818e8e293</citedby><cites>FETCH-LOGICAL-c250t-d7354de8dda767551f63360210a7e377637def995b803aa85f33de27818e8e293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/199118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kassis, V</creatorcontrib><creatorcontrib>Weismann, K</creatorcontrib><creatorcontrib>Heiligstädt, H</creatorcontrib><creatorcontrib>Sondergaard, J</creatorcontrib><title>Synthesis of prostaglandins by psoriatic skin</title><title>Archives for Dermatological Research</title><addtitle>Arch Dermatol Res</addtitle><description>The biosynthesis of prostaglandins (PG) in biopsies from 9 patients with psoriasis was studied. The involved as well as the uninvolved psoriatic skin showed a statistically significant decrease of the ability to synthesize PG's. In PGE1-equivalents the concentration (mean +/- S.E.M.) was 4.41 +/- 0.48 ng/g wet weight in the psoriatic lesion, 5.41 +/- 0.64 ng/g wet weight in uninvolved psoriatic skin in the presence of exogenous arachidonic acid in the incubation medium as compared with 9.02 +/- 1.59 in normal human skin. When the skin was incubated without excess of exogenous precursor acid the activity formed was similarly significantly lower in psoriatic skin as compared with normal skin. A disturbed balance between E and F PG synthesis was not demonstrated, which might have accounted for the postulated altered intracellular ratio of cyclic AMP to cyclic GMP in psoriatic skin.</description><subject>Adenosine Monophosphate - metabolism</subject><subject>Arachidonic Acids - metabolism</subject><subject>Cyclic AMP - metabolism</subject><subject>Humans</subject><subject>Prostaglandins - biosynthesis</subject><subject>Psoriasis - metabolism</subject><subject>Skin - metabolism</subject><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFjztPwzAUhS3EKypdmBkyIxmuff0coaKAVIkBkNgiJ7bB0KZRHIb8ewJF6lnO8unofIScM7hiAPr6dgkgFRPCHJCCCeQUlH07JAWgAIrKqlMyz_kTpmgQHPQJOWbWMmYKQp_HdvgIOeVyG8uu3-bBva9d61Oby3osu7ztkxtSU-av1J6Ro-jWOcz_e0Zel3cviwe6erp_XNysaMMlDNRrlMIH473TSkvJokJUwBk4HVBrhdqHaK2sDaBzRkZEH7g2zAQTuMUZudztNtOh3IdYdX3auH6sGFS_0tVeeoIvdnD3XW-C36N_ivgDhOpPmw</recordid><startdate>19770101</startdate><enddate>19770101</enddate><creator>Kassis, V</creator><creator>Weismann, K</creator><creator>Heiligstädt, H</creator><creator>Sondergaard, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19770101</creationdate><title>Synthesis of prostaglandins by psoriatic skin</title><author>Kassis, V ; Weismann, K ; Heiligstädt, H ; Sondergaard, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-d7354de8dda767551f63360210a7e377637def995b803aa85f33de27818e8e293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adenosine Monophosphate - metabolism</topic><topic>Arachidonic Acids - metabolism</topic><topic>Cyclic AMP - metabolism</topic><topic>Humans</topic><topic>Prostaglandins - biosynthesis</topic><topic>Psoriasis - metabolism</topic><topic>Skin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kassis, V</creatorcontrib><creatorcontrib>Weismann, K</creatorcontrib><creatorcontrib>Heiligstädt, H</creatorcontrib><creatorcontrib>Sondergaard, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Archives for Dermatological Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kassis, V</au><au>Weismann, K</au><au>Heiligstädt, H</au><au>Sondergaard, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of prostaglandins by psoriatic skin</atitle><jtitle>Archives for Dermatological Research</jtitle><addtitle>Arch Dermatol Res</addtitle><date>1977-01-01</date><risdate>1977</risdate><volume>259</volume><issue>3</issue><spage>207</spage><epage>212</epage><pages>207-212</pages><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>The biosynthesis of prostaglandins (PG) in biopsies from 9 patients with psoriasis was studied. The involved as well as the uninvolved psoriatic skin showed a statistically significant decrease of the ability to synthesize PG's. In PGE1-equivalents the concentration (mean +/- S.E.M.) was 4.41 +/- 0.48 ng/g wet weight in the psoriatic lesion, 5.41 +/- 0.64 ng/g wet weight in uninvolved psoriatic skin in the presence of exogenous arachidonic acid in the incubation medium as compared with 9.02 +/- 1.59 in normal human skin. When the skin was incubated without excess of exogenous precursor acid the activity formed was similarly significantly lower in psoriatic skin as compared with normal skin. A disturbed balance between E and F PG synthesis was not demonstrated, which might have accounted for the postulated altered intracellular ratio of cyclic AMP to cyclic GMP in psoriatic skin.</abstract><cop>Germany</cop><pmid>199118</pmid><doi>10.1007/BF00561448</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-3696 |
| ispartof | Archives for Dermatological Research, 1977-01, Vol.259 (3), p.207-212 |
| issn | 0340-3696 1432-069X |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00561448 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adenosine Monophosphate - metabolism Arachidonic Acids - metabolism Cyclic AMP - metabolism Humans Prostaglandins - biosynthesis Psoriasis - metabolism Skin - metabolism |
| title | Synthesis of prostaglandins by psoriatic skin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T03%3A30%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20of%20prostaglandins%20by%20psoriatic%20skin&rft.jtitle=Archives%20for%20Dermatological%20Research&rft.au=Kassis,%20V&rft.date=1977-01-01&rft.volume=259&rft.issue=3&rft.spage=207&rft.epage=212&rft.pages=207-212&rft.issn=0340-3696&rft.eissn=1432-069X&rft_id=info:doi/10.1007/BF00561448&rft_dat=%3Cpubmed_cross%3E199118%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/199118&rfr_iscdi=true |