Electrocardiographic and hemodynamic effects of tocainide (W-36095) in man
Tocainide is a new antiarrhythmic drug with a chemical structure related to that of lidocaine. In the present study, healthy volunteers were investigated after infusion of tocainide 450 mg over 45 min. In nine subjects His bundle electrograms, sinus recovery time and ventricular effective refractory...
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| Veröffentlicht in: | European journal of clinical pharmacology 1978-01, Vol.14 (1), p.15-19 |
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| container_title | European journal of clinical pharmacology |
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| creator | Swedberg, K Pehrson, J Rydén, L |
| description | Tocainide is a new antiarrhythmic drug with a chemical structure related to that of lidocaine. In the present study, healthy volunteers were investigated after infusion of tocainide 450 mg over 45 min. In nine subjects His bundle electrograms, sinus recovery time and ventricular effective refractory periods were recorded. No major changes were seen. In eight cases the hemodynamic effects at rest and during exercise were studied. No significant circulatory effects were observed. No clinically important side-effects were noted. |
| doi_str_mv | 10.1007/BF00560253 |
| format | Article |
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In the present study, healthy volunteers were investigated after infusion of tocainide 450 mg over 45 min. In nine subjects His bundle electrograms, sinus recovery time and ventricular effective refractory periods were recorded. No major changes were seen. In eight cases the hemodynamic effects at rest and during exercise were studied. No significant circulatory effects were observed. 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In the present study, healthy volunteers were investigated after infusion of tocainide 450 mg over 45 min. In nine subjects His bundle electrograms, sinus recovery time and ventricular effective refractory periods were recorded. No major changes were seen. In eight cases the hemodynamic effects at rest and during exercise were studied. No significant circulatory effects were observed. No clinically important side-effects were noted.</description><subject>Adult</subject><subject>Anilides - adverse effects</subject><subject>Anilides - blood</subject><subject>Anilides - pharmacology</subject><subject>Anti-Arrhythmia Agents - adverse effects</subject><subject>Anti-Arrhythmia Agents - blood</subject><subject>Anti-Arrhythmia Agents - pharmacology</subject><subject>Electrocardiography</subject><subject>Heart Conduction System - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Refractory Period, Electrophysiological - drug effects</subject><subject>Sinoatrial Node - drug effects</subject><subject>Time Factors</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0ElLxEAQBeBG3OLoxbOHPqoQrUpv00cdZlwY8KJ4DJXujhOZLHTiYf69kYieHg8-Cuoxdo5wgwDm9n4FoDRkSuyxBKXIUgSJ-ywBEJhqa-CYnfT9JwAqC-KIHZrMjj5hz8ttcENsHUVftR-Ruk3lODWeb0Ld-l1D9dhDWY6q523Jh5FWTeUDv3xPhQarrnjV8JqaU3ZQ0rYPZ785Y2-r5eviMV2_PDwt7tapy-Y4pMY4VOCDJCWFEVIioAZDZALIQgUqgrQ6I9AkpCc3RyuUMaCE06W1mZix6-mui23fx1DmXaxqirscIf-ZI_-fY8QXE-6-ijr4Pzr9L74BeAlXKg</recordid><startdate>19780101</startdate><enddate>19780101</enddate><creator>Swedberg, K</creator><creator>Pehrson, J</creator><creator>Rydén, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19780101</creationdate><title>Electrocardiographic and hemodynamic effects of tocainide (W-36095) in man</title><author>Swedberg, K ; Pehrson, J ; Rydén, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-77c150de4a5437344101607aa7e04b5eabe4962a06a34dac8193577053c6f9923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adult</topic><topic>Anilides - adverse effects</topic><topic>Anilides - blood</topic><topic>Anilides - pharmacology</topic><topic>Anti-Arrhythmia Agents - adverse effects</topic><topic>Anti-Arrhythmia Agents - blood</topic><topic>Anti-Arrhythmia Agents - pharmacology</topic><topic>Electrocardiography</topic><topic>Heart Conduction System - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Refractory Period, Electrophysiological - drug effects</topic><topic>Sinoatrial Node - drug effects</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Swedberg, K</creatorcontrib><creatorcontrib>Pehrson, J</creatorcontrib><creatorcontrib>Rydén, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Swedberg, K</au><au>Pehrson, J</au><au>Rydén, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrocardiographic and hemodynamic effects of tocainide (W-36095) in man</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1978-01-01</date><risdate>1978</risdate><volume>14</volume><issue>1</issue><spage>15</spage><epage>19</epage><pages>15-19</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Tocainide is a new antiarrhythmic drug with a chemical structure related to that of lidocaine. 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| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 1978-01, Vol.14 (1), p.15-19 |
| issn | 0031-6970 1432-1041 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00560253 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Anilides - adverse effects Anilides - blood Anilides - pharmacology Anti-Arrhythmia Agents - adverse effects Anti-Arrhythmia Agents - blood Anti-Arrhythmia Agents - pharmacology Electrocardiography Heart Conduction System - drug effects Hemodynamics - drug effects Humans Refractory Period, Electrophysiological - drug effects Sinoatrial Node - drug effects Time Factors |
| title | Electrocardiographic and hemodynamic effects of tocainide (W-36095) in man |
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