Acetylation polymorphism and leprosy

The sulfones are the drug of choice in the treatment of leprosy, with dapsone as the clear favorite. The major route for dapsone metabolism leading to its inactivation and excretion is via acetylation by hepatic N-acetyl transferase (NAT), as is the case with isoniazid (INH) and sulfamethazine (SMZ)...

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Veröffentlicht in:	Biochemical genetics 1990-02, Vol.28 (1-2), p.1-7
Hauptverfasser:	EZE, L. C, OKPOGBA, A. N, OGAN, A. U
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetyltransferases - genetics Biological and medical sciences General pharmacology Humans Incidence Leprosy - genetics Medical sciences Nigeria Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Phenotype Polymorphism, Genetic Sulfamethazine - adverse effects Sulfamethazine - blood Sulfamethazine - therapeutic use Sulfamethazine - urine
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