Amiodarone and pulmonary fibrosis

Amiodarone and pulmonary fibrosis

Of 25 cases of idiopathic pulmonary fibrosis, confirmed by open chest lung biopsy between January 1979 and July 1981, 5 patients had been taking amiodarone in doses less than 600 mg daily for 1 to 6 years. No lung disease had been observed in any patient before the administration of amiodarone, and...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of clinical pharmacology 1983-01, Vol.24 (5), p.591-593
Hauptverfasser: Morera, J, Vidal, R, Morell, F, Ruiz, J, Bernadó, L, Laporte, J R
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Amiodarone - adverse effects
Benzofurans - adverse effects
Female
Humans
Male
Middle Aged
Pulmonary Fibrosis - chemically induced
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 593
container_issue 5
container_start_page 591
container_title European journal of clinical pharmacology
container_volume 24
creator Morera, J
Vidal, R
Morell, F
Ruiz, J
Bernadó, L
Laporte, J R
description Of 25 cases of idiopathic pulmonary fibrosis, confirmed by open chest lung biopsy between January 1979 and July 1981, 5 patients had been taking amiodarone in doses less than 600 mg daily for 1 to 6 years. No lung disease had been observed in any patient before the administration of amiodarone, and other drugs, factors and diseases thought to play a role in the causation of pulmonary fibrosis were ruled out. Two patients died of respiratory insufficiency, and only 1 does not now suffer from serious sequelae. Review of a further 5 cases reported in the literature and the present data suggest a causal link between administration of amiodarone and pulmonary fibrosis, and tend to indicate a hypersensitivity mechanism.
doi_str_mv 10.1007/BF00542206
format Article
fullrecord <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF00542206</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>6873135</sourcerecordid><originalsourceid>FETCH-LOGICAL-c282t-74685e541da2e0c755f950702d6879cc294c1f32aea2ecd19688e1f2b9edef023</originalsourceid><addsrcrecordid>eNpFj0tLAzEUhYModaxu3AvjVhi99yaZJMtarAoFN7oeMnnASOfBxC7890ZadHUW9-Oe8zF2jXCPAOrhcQMgBRHUJ6xAwalCEHjKCgCOVW0UnLOLlD4BUBrgC7aoteLIZcFuV303ejuPQyjt4Mtpv-vHwc7fZezaeUxdumRn0e5SuDrmkn1snt7XL9X27fl1vdpWjjR9VUrUWgYp0FsK4JSU0UhQQD53GefICIeRkw357jyaWuuAkVoTfIhAfMnuDn9drk1ziM00d31e0iA0v5rNv2aGbw7wtG_74P_Qoxf_AbSNSyI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Amiodarone and pulmonary fibrosis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Morera, J ; Vidal, R ; Morell, F ; Ruiz, J ; Bernadó, L ; Laporte, J R</creator><creatorcontrib>Morera, J ; Vidal, R ; Morell, F ; Ruiz, J ; Bernadó, L ; Laporte, J R</creatorcontrib><description>Of 25 cases of idiopathic pulmonary fibrosis, confirmed by open chest lung biopsy between January 1979 and July 1981, 5 patients had been taking amiodarone in doses less than 600 mg daily for 1 to 6 years. No lung disease had been observed in any patient before the administration of amiodarone, and other drugs, factors and diseases thought to play a role in the causation of pulmonary fibrosis were ruled out. Two patients died of respiratory insufficiency, and only 1 does not now suffer from serious sequelae. Review of a further 5 cases reported in the literature and the present data suggest a causal link between administration of amiodarone and pulmonary fibrosis, and tend to indicate a hypersensitivity mechanism.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00542206</identifier><identifier>PMID: 6873135</identifier><language>eng</language><publisher>Germany</publisher><subject>Aged ; Amiodarone - adverse effects ; Benzofurans - adverse effects ; Female ; Humans ; Male ; Middle Aged ; Pulmonary Fibrosis - chemically induced</subject><ispartof>European journal of clinical pharmacology, 1983-01, Vol.24 (5), p.591-593</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-74685e541da2e0c755f950702d6879cc294c1f32aea2ecd19688e1f2b9edef023</citedby><cites>FETCH-LOGICAL-c282t-74685e541da2e0c755f950702d6879cc294c1f32aea2ecd19688e1f2b9edef023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6873135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morera, J</creatorcontrib><creatorcontrib>Vidal, R</creatorcontrib><creatorcontrib>Morell, F</creatorcontrib><creatorcontrib>Ruiz, J</creatorcontrib><creatorcontrib>Bernadó, L</creatorcontrib><creatorcontrib>Laporte, J R</creatorcontrib><title>Amiodarone and pulmonary fibrosis</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>Of 25 cases of idiopathic pulmonary fibrosis, confirmed by open chest lung biopsy between January 1979 and July 1981, 5 patients had been taking amiodarone in doses less than 600 mg daily for 1 to 6 years. No lung disease had been observed in any patient before the administration of amiodarone, and other drugs, factors and diseases thought to play a role in the causation of pulmonary fibrosis were ruled out. Two patients died of respiratory insufficiency, and only 1 does not now suffer from serious sequelae. Review of a further 5 cases reported in the literature and the present data suggest a causal link between administration of amiodarone and pulmonary fibrosis, and tend to indicate a hypersensitivity mechanism.</description><subject>Aged</subject><subject>Amiodarone - adverse effects</subject><subject>Benzofurans - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pulmonary Fibrosis - chemically induced</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj0tLAzEUhYModaxu3AvjVhi99yaZJMtarAoFN7oeMnnASOfBxC7890ZadHUW9-Oe8zF2jXCPAOrhcQMgBRHUJ6xAwalCEHjKCgCOVW0UnLOLlD4BUBrgC7aoteLIZcFuV303ejuPQyjt4Mtpv-vHwc7fZezaeUxdumRn0e5SuDrmkn1snt7XL9X27fl1vdpWjjR9VUrUWgYp0FsK4JSU0UhQQD53GefICIeRkw357jyaWuuAkVoTfIhAfMnuDn9drk1ziM00d31e0iA0v5rNv2aGbw7wtG_74P_Qoxf_AbSNSyI</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Morera, J</creator><creator>Vidal, R</creator><creator>Morell, F</creator><creator>Ruiz, J</creator><creator>Bernadó, L</creator><creator>Laporte, J R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19830101</creationdate><title>Amiodarone and pulmonary fibrosis</title><author>Morera, J ; Vidal, R ; Morell, F ; Ruiz, J ; Bernadó, L ; Laporte, J R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-74685e541da2e0c755f950702d6879cc294c1f32aea2ecd19688e1f2b9edef023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Aged</topic><topic>Amiodarone - adverse effects</topic><topic>Benzofurans - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pulmonary Fibrosis - chemically induced</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morera, J</creatorcontrib><creatorcontrib>Vidal, R</creatorcontrib><creatorcontrib>Morell, F</creatorcontrib><creatorcontrib>Ruiz, J</creatorcontrib><creatorcontrib>Bernadó, L</creatorcontrib><creatorcontrib>Laporte, J R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morera, J</au><au>Vidal, R</au><au>Morell, F</au><au>Ruiz, J</au><au>Bernadó, L</au><au>Laporte, J R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amiodarone and pulmonary fibrosis</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>24</volume><issue>5</issue><spage>591</spage><epage>593</epage><pages>591-593</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Of 25 cases of idiopathic pulmonary fibrosis, confirmed by open chest lung biopsy between January 1979 and July 1981, 5 patients had been taking amiodarone in doses less than 600 mg daily for 1 to 6 years. No lung disease had been observed in any patient before the administration of amiodarone, and other drugs, factors and diseases thought to play a role in the causation of pulmonary fibrosis were ruled out. Two patients died of respiratory insufficiency, and only 1 does not now suffer from serious sequelae. Review of a further 5 cases reported in the literature and the present data suggest a causal link between administration of amiodarone and pulmonary fibrosis, and tend to indicate a hypersensitivity mechanism.</abstract><cop>Germany</cop><pmid>6873135</pmid><doi>10.1007/BF00542206</doi><tpages>3</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0031-6970
ispartof European journal of clinical pharmacology, 1983-01, Vol.24 (5), p.591-593
issn 0031-6970
1432-1041
language eng
recordid cdi_crossref_primary_10_1007_BF00542206
source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Aged
Amiodarone - adverse effects
Benzofurans - adverse effects
Female
Humans
Male
Middle Aged
Pulmonary Fibrosis - chemically induced
title Amiodarone and pulmonary fibrosis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T15%3A34%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Amiodarone%20and%20pulmonary%20fibrosis&rft.jtitle=European%20journal%20of%20clinical%20pharmacology&rft.au=Morera,%20J&rft.date=1983-01-01&rft.volume=24&rft.issue=5&rft.spage=591&rft.epage=593&rft.pages=591-593&rft.issn=0031-6970&rft.eissn=1432-1041&rft_id=info:doi/10.1007/BF00542206&rft_dat=%3Cpubmed_cross%3E6873135%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/6873135&rfr_iscdi=true