Effect of halothane anaesthesia on salivary elimination of paracetamol
The effect of halothane anaesthesia on paracetamol elimination was studied in 6 male patients undergoing short surgical procedures. Seven males operated on for the same indications under epidural anaesthesia served as the control group. Paracetamol concentration in saliva was measured at intervals o...
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| Veröffentlicht in: | European journal of clinical pharmacology 1986-01, Vol.30 (3), p.371-373 |
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| container_end_page | 373 |
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| container_issue | 3 |
| container_start_page | 371 |
| container_title | European journal of clinical pharmacology |
| container_volume | 30 |
| creator | RAY, K ADITHAN, C BAPNA, J. S KAMATCHI, G. L RAY, K MEHTA, R. B |
| description | The effect of halothane anaesthesia on paracetamol elimination was studied in 6 male patients undergoing short surgical procedures. Seven males operated on for the same indications under epidural anaesthesia served as the control group. Paracetamol concentration in saliva was measured at intervals on the day before and after surgery. Paracetamol t1/2 significantly decreased from 2.1 to 0.96 h and clearance rate (CL) significantly increased from 8.7 to 17.0 ml min-1 kg-1, when compared with the preoperative values. The control group also showed a significant but smaller alteration in the parameters. The results suggest that halothane anaesthesia per se may enhance the hepatic metabolism of paracetamol. |
| doi_str_mv | 10.1007/BF00541548 |
| format | Article |
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S ; KAMATCHI, G. L ; RAY, K ; MEHTA, R. B</creator><creatorcontrib>RAY, K ; ADITHAN, C ; BAPNA, J. S ; KAMATCHI, G. L ; RAY, K ; MEHTA, R. B</creatorcontrib><description>The effect of halothane anaesthesia on paracetamol elimination was studied in 6 male patients undergoing short surgical procedures. Seven males operated on for the same indications under epidural anaesthesia served as the control group. Paracetamol concentration in saliva was measured at intervals on the day before and after surgery. Paracetamol t1/2 significantly decreased from 2.1 to 0.96 h and clearance rate (CL) significantly increased from 8.7 to 17.0 ml min-1 kg-1, when compared with the preoperative values. The control group also showed a significant but smaller alteration in the parameters. The results suggest that halothane anaesthesia per se may enhance the hepatic metabolism of paracetamol.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00541548</identifier><identifier>PMID: 3732379</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Acetaminophen - metabolism ; Adult ; Analgesics ; Anesthesia, Epidural ; Anesthesia, Inhalation ; Biological and medical sciences ; Halothane - adverse effects ; Humans ; Kinetics ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. 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S</creatorcontrib><creatorcontrib>KAMATCHI, G. L</creatorcontrib><creatorcontrib>RAY, K</creatorcontrib><creatorcontrib>MEHTA, R. B</creatorcontrib><title>Effect of halothane anaesthesia on salivary elimination of paracetamol</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>The effect of halothane anaesthesia on paracetamol elimination was studied in 6 male patients undergoing short surgical procedures. Seven males operated on for the same indications under epidural anaesthesia served as the control group. Paracetamol concentration in saliva was measured at intervals on the day before and after surgery. Paracetamol t1/2 significantly decreased from 2.1 to 0.96 h and clearance rate (CL) significantly increased from 8.7 to 17.0 ml min-1 kg-1, when compared with the preoperative values. The control group also showed a significant but smaller alteration in the parameters. The results suggest that halothane anaesthesia per se may enhance the hepatic metabolism of paracetamol.</description><subject>Acetaminophen - metabolism</subject><subject>Adult</subject><subject>Analgesics</subject><subject>Anesthesia, Epidural</subject><subject>Anesthesia, Inhalation</subject><subject>Biological and medical sciences</subject><subject>Halothane - adverse effects</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Saliva - metabolism</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRaq1evAs5eBKiM5lsdveopVWh4EXPYbofNJKPko2C_95IQz0NzPPMMPMKcY1wjwDq4WkNIHOUuT4Rc8wpSxFyPBVzAMK0MArOxUWMnwAoDdBMzEhRRsrMxXoVgrdD0oVkx3U37Lj1Cbfs47DzseKka5PIdfXN_U_i66qpWh6qsTkO7Lln6wduuvpSnAWuo7-a6kJ8rFfvy5d08_b8unzcpJYQh7QASzlupQOJSkFAF3IwztjMZYisjfRyJCEji5pVEcihzrzW0pEL3tNC3B322r6Lsfeh3PdVM95WIpR_WZT_WYzyzUHef20b747q9PzIbyfO0XIdem5tFY-a0qowpOkXZXVlPA</recordid><startdate>19860101</startdate><enddate>19860101</enddate><creator>RAY, K</creator><creator>ADITHAN, C</creator><creator>BAPNA, J. S</creator><creator>KAMATCHI, G. L</creator><creator>RAY, K</creator><creator>MEHTA, R. B</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19860101</creationdate><title>Effect of halothane anaesthesia on salivary elimination of paracetamol</title><author>RAY, K ; ADITHAN, C ; BAPNA, J. S ; KAMATCHI, G. L ; RAY, K ; MEHTA, R. B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-60c341b5d051770f1df409d9c2d211a895e5517f23c18a76f3d182e885d3dfee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Acetaminophen - metabolism</topic><topic>Adult</topic><topic>Analgesics</topic><topic>Anesthesia, Epidural</topic><topic>Anesthesia, Inhalation</topic><topic>Biological and medical sciences</topic><topic>Halothane - adverse effects</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Saliva - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RAY, K</creatorcontrib><creatorcontrib>ADITHAN, C</creatorcontrib><creatorcontrib>BAPNA, J. S</creatorcontrib><creatorcontrib>KAMATCHI, G. L</creatorcontrib><creatorcontrib>RAY, K</creatorcontrib><creatorcontrib>MEHTA, R. B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RAY, K</au><au>ADITHAN, C</au><au>BAPNA, J. S</au><au>KAMATCHI, G. L</au><au>RAY, K</au><au>MEHTA, R. B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of halothane anaesthesia on salivary elimination of paracetamol</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1986-01-01</date><risdate>1986</risdate><volume>30</volume><issue>3</issue><spage>371</spage><epage>373</epage><pages>371-373</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>The effect of halothane anaesthesia on paracetamol elimination was studied in 6 male patients undergoing short surgical procedures. Seven males operated on for the same indications under epidural anaesthesia served as the control group. Paracetamol concentration in saliva was measured at intervals on the day before and after surgery. Paracetamol t1/2 significantly decreased from 2.1 to 0.96 h and clearance rate (CL) significantly increased from 8.7 to 17.0 ml min-1 kg-1, when compared with the preoperative values. The control group also showed a significant but smaller alteration in the parameters. The results suggest that halothane anaesthesia per se may enhance the hepatic metabolism of paracetamol.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>3732379</pmid><doi>10.1007/BF00541548</doi><tpages>3</tpages></addata></record> |
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| ispartof | European journal of clinical pharmacology, 1986-01, Vol.30 (3), p.371-373 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acetaminophen - metabolism Adult Analgesics Anesthesia, Epidural Anesthesia, Inhalation Biological and medical sciences Halothane - adverse effects Humans Kinetics Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Saliva - metabolism |
| title | Effect of halothane anaesthesia on salivary elimination of paracetamol |
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