Do antidepressants cause postural hypotension by blocking cardiovascular reflexes?
Postural changes in blood pressure, respiratory sinus arrhythmia, the heart rate response to Valsalva's manoeuvre and to standing, and the blood pressure and heart rate responses to isometric exercise have been measured in seven young women taking antidepressant medication and compared with sev...
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| Veröffentlicht in: | European journal of clinical pharmacology 1987-01, Vol.31 (6), p.647-653 |
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| container_end_page | 653 |
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| container_issue | 6 |
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| container_title | European journal of clinical pharmacology |
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| creator | MIDDLETON, H. C MAISEY, D. N MILLS, I. H |
| description | Postural changes in blood pressure, respiratory sinus arrhythmia, the heart rate response to Valsalva's manoeuvre and to standing, and the blood pressure and heart rate responses to isometric exercise have been measured in seven young women taking antidepressant medication and compared with seven controls. Among the patients there was a significant rank order correlation between the degree of postural hypotension and the daily dose of antidepressant medication. There was a significant impairment among the patients of all cardiovascular reflex responses measured, suggesting both cholinergic and adrenergic blockade. These results suggest that postural hypotension associated with antidepressant medication is caused in large part by a failure of reflex peripheral vasoconstriction. |
| doi_str_mv | 10.1007/BF00541290 |
| format | Article |
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These results suggest that postural hypotension associated with antidepressant medication is caused in large part by a failure of reflex peripheral vasoconstriction.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00541290</identifier><identifier>PMID: 3830251</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Antidepressive Agents - adverse effects ; Arrhythmias, Cardiac - chemically induced ; Biological and medical sciences ; Blood Pressure - drug effects ; Female ; Heart Rate - drug effects ; Humans ; Hypotension, Orthostatic - chemically induced ; Isometric Contraction ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. 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C</creatorcontrib><creatorcontrib>MAISEY, D. N</creatorcontrib><creatorcontrib>MILLS, I. H</creatorcontrib><title>Do antidepressants cause postural hypotension by blocking cardiovascular reflexes?</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>Postural changes in blood pressure, respiratory sinus arrhythmia, the heart rate response to Valsalva's manoeuvre and to standing, and the blood pressure and heart rate responses to isometric exercise have been measured in seven young women taking antidepressant medication and compared with seven controls. Among the patients there was a significant rank order correlation between the degree of postural hypotension and the daily dose of antidepressant medication. There was a significant impairment among the patients of all cardiovascular reflex responses measured, suggesting both cholinergic and adrenergic blockade. These results suggest that postural hypotension associated with antidepressant medication is caused in large part by a failure of reflex peripheral vasoconstriction.</description><subject>Antidepressive Agents - adverse effects</subject><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Hypotension, Orthostatic - chemically induced</subject><subject>Isometric Contraction</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Reflex - drug effects</subject><subject>Valsalva Maneuver</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1Lw0AQxRdRaq1evAt78CREZ7_ycRKtVoWCIHoOk82uRtNs2E3E_veutNTTDLwfb-Y9Qk4ZXDKA7Op2AaAk4wXskSmTgicMJNsnUwDBkrTI4JAchfAJwFQBYkImIhfAFZuSlztHsRua2vTehBDXQDWOwdDehWH02NKPde8G04XGdbRa06p1-qvp3iPm68Z9Y9Bji556Y1vzY8L1MTmw2AZzsp0z8ra4f50_Jsvnh6f5zTLRgrEhEUJwoVJm06LKVZbVtQZdpZmtpKrA5GnGkUERP065RmlRW4OISmlpY1QpZuRi46u9CyGeL3vfrNCvSwblXy_lfy8RPtvA_VitTL1Dt0VE_XyrxzzYWo-dbsIOy3kuIiV-ATRSaro</recordid><startdate>19870101</startdate><enddate>19870101</enddate><creator>MIDDLETON, H. C</creator><creator>MAISEY, D. N</creator><creator>MILLS, I. H</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19870101</creationdate><title>Do antidepressants cause postural hypotension by blocking cardiovascular reflexes?</title><author>MIDDLETON, H. C ; MAISEY, D. N ; MILLS, I. 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Psychiatry</topic><topic>Psychopharmacology</topic><topic>Reflex - drug effects</topic><topic>Valsalva Maneuver</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MIDDLETON, H. C</creatorcontrib><creatorcontrib>MAISEY, D. N</creatorcontrib><creatorcontrib>MILLS, I. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MIDDLETON, H. C</au><au>MAISEY, D. N</au><au>MILLS, I. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do antidepressants cause postural hypotension by blocking cardiovascular reflexes?</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1987-01-01</date><risdate>1987</risdate><volume>31</volume><issue>6</issue><spage>647</spage><epage>653</epage><pages>647-653</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Postural changes in blood pressure, respiratory sinus arrhythmia, the heart rate response to Valsalva's manoeuvre and to standing, and the blood pressure and heart rate responses to isometric exercise have been measured in seven young women taking antidepressant medication and compared with seven controls. Among the patients there was a significant rank order correlation between the degree of postural hypotension and the daily dose of antidepressant medication. There was a significant impairment among the patients of all cardiovascular reflex responses measured, suggesting both cholinergic and adrenergic blockade. These results suggest that postural hypotension associated with antidepressant medication is caused in large part by a failure of reflex peripheral vasoconstriction.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>3830251</pmid><doi>10.1007/BF00541290</doi><tpages>7</tpages></addata></record> |
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| ispartof | European journal of clinical pharmacology, 1987-01, Vol.31 (6), p.647-653 |
| issn | 0031-6970 1432-1041 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Antidepressive Agents - adverse effects Arrhythmias, Cardiac - chemically induced Biological and medical sciences Blood Pressure - drug effects Female Heart Rate - drug effects Humans Hypotension, Orthostatic - chemically induced Isometric Contraction Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Reflex - drug effects Valsalva Maneuver |
| title | Do antidepressants cause postural hypotension by blocking cardiovascular reflexes? |
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