Myofibroblasts in focal nodular hyperplasia of the liver
Myofibroblasts have been identified by electron microscopy in a case of Focal Nodular Hyperplasia (FNH) of the liver associated with oral contraceptives. The contractile fibroblasts were observed in the immediate vicinity of, or in close contact with, the proliferating bile ductules and in the reces...
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| Veröffentlicht in: | Virchows Archiv A Pathological Anatomy and Histology 1982-01, Vol.396 (2), p.155-166 |
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| container_end_page | 166 |
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| container_issue | 2 |
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| container_title | Virchows Archiv A Pathological Anatomy and Histology |
| container_volume | 396 |
| creator | Callea, F Mebis, J Desmet, V J |
| description | Myofibroblasts have been identified by electron microscopy in a case of Focal Nodular Hyperplasia (FNH) of the liver associated with oral contraceptives. The contractile fibroblasts were observed in the immediate vicinity of, or in close contact with, the proliferating bile ductules and in the recesses between parenchymal cells. Transitional forms between fat-storing cells (Ito cells), fibroblasts and myofribroblasts were observed. Transition of fat-storing cells to myofibroblasts, possibly under the influence of oestrogens, may be responsible for the fibrosis and retraction in FNH. |
| doi_str_mv | 10.1007/bf00431238 |
| format | Article |
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The contractile fibroblasts were observed in the immediate vicinity of, or in close contact with, the proliferating bile ductules and in the recesses between parenchymal cells. Transitional forms between fat-storing cells (Ito cells), fibroblasts and myofribroblasts were observed. Transition of fat-storing cells to myofibroblasts, possibly under the influence of oestrogens, may be responsible for the fibrosis and retraction in FNH.</description><subject>Adult</subject><subject>Contraceptives, Oral - adverse effects</subject><subject>Cytoskeleton - ultrastructure</subject><subject>Female</subject><subject>Fibroblasts - metabolism</subject><subject>Fibroblasts - ultrastructure</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Lipid Metabolism</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver - ultrastructure</subject><issn>0340-1227</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j8FLwzAYxYMos04v3oWcher3JW2THnU4FSZe9FzSJB-rdEtJOqH_vZNNT-_B-_Hgx9g1wh0CqPuWAAqJQuoTlmEhRS4kqFOWgSwgRyHUObtI6QugLFHLGZtVWtdKi4zptylQ18bQ9iaNiXdbTsGanm-D2_Um8vU0-Djsx87wQHxce9533z5esjMyffJXx5yzz-XTx-IlX70_vy4eVrmVSo25oxoKMKjKCr0zttBeIzq7L6WwrUdJRKWqjNCE4GylKsAaUdTOeqWEnLPbw6-NIaXoqRlitzFxahCaX_vmcflnv4dvDvCwazfe_aNHXfkD51NUEg</recordid><startdate>19820101</startdate><enddate>19820101</enddate><creator>Callea, F</creator><creator>Mebis, J</creator><creator>Desmet, V J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19820101</creationdate><title>Myofibroblasts in focal nodular hyperplasia of the liver</title><author>Callea, F ; Mebis, J ; Desmet, V J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-df9040a17561edac48e811dcc4852cbe13fff576a28f10dc6760191129dce7723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Contraceptives, Oral - adverse effects</topic><topic>Cytoskeleton - ultrastructure</topic><topic>Female</topic><topic>Fibroblasts - metabolism</topic><topic>Fibroblasts - ultrastructure</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Lipid Metabolism</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Callea, F</creatorcontrib><creatorcontrib>Mebis, J</creatorcontrib><creatorcontrib>Desmet, V J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Virchows Archiv A Pathological Anatomy and Histology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Callea, F</au><au>Mebis, J</au><au>Desmet, V J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myofibroblasts in focal nodular hyperplasia of the liver</atitle><jtitle>Virchows Archiv A Pathological Anatomy and Histology</jtitle><addtitle>Virchows Arch A Pathol Anat Histol</addtitle><date>1982-01-01</date><risdate>1982</risdate><volume>396</volume><issue>2</issue><spage>155</spage><epage>166</epage><pages>155-166</pages><issn>0340-1227</issn><eissn>1432-2307</eissn><abstract>Myofibroblasts have been identified by electron microscopy in a case of Focal Nodular Hyperplasia (FNH) of the liver associated with oral contraceptives. 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| fulltext | fulltext |
| identifier | ISSN: 0340-1227 |
| ispartof | Virchows Archiv A Pathological Anatomy and Histology, 1982-01, Vol.396 (2), p.155-166 |
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| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00431238 |
| source | MEDLINE; SpringerLink (Online service) |
| subjects | Adult Contraceptives, Oral - adverse effects Cytoskeleton - ultrastructure Female Fibroblasts - metabolism Fibroblasts - ultrastructure Histocytochemistry Humans Hyperplasia Lipid Metabolism Liver - metabolism Liver - pathology Liver - ultrastructure |
| title | Myofibroblasts in focal nodular hyperplasia of the liver |
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