Inhibition of benzo(a)pyrene carcinogenesis in rats with vitamin C
The s.c. infection of 10 mg benzo(a)pyrene dissolved in 1 ml tricaprylin induced in Wistar rats local malignant tumors, such as fibrosarcoma, rhabdomyosarcoma, and polymorph cell sarcoma. The growth of the tumors was relatively rapid, reaching weights of 140-155 g before rats died 142-168 days after...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 1980-01, Vol.97 (1), p.91-96 |
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| container_title | Journal of cancer research and clinical oncology |
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| creator | Kallistratos, G Fasske, E |
| description | The s.c. infection of 10 mg benzo(a)pyrene dissolved in 1 ml tricaprylin induced in Wistar rats local malignant tumors, such as fibrosarcoma, rhabdomyosarcoma, and polymorph cell sarcoma. The growth of the tumors was relatively rapid, reaching weights of 140-155 g before rats died 142-168 days after the administration of the carcinogen. On the contrary, under the same experimental conditions, high doses of Vitamin C about 525 mg/day/rat administered orally in drinking water (total amount of Vitamin C 55 g/rat corresponding to 40% of their body weight ) inhibited to a great extent the benzo(a)pyrene carcinogenesis. Only one slowly growing rhabdomyosarcoma (13 g of weight) was developed showing characteristic damage of malignant cells and partial replacement of the neoplastic area with granuloma tissue. The significance ov Vitamin C for cancer prevention and treatment is discussed. |
| doi_str_mv | 10.1007/BF00411283 |
| format | Article |
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The growth of the tumors was relatively rapid, reaching weights of 140-155 g before rats died 142-168 days after the administration of the carcinogen. On the contrary, under the same experimental conditions, high doses of Vitamin C about 525 mg/day/rat administered orally in drinking water (total amount of Vitamin C 55 g/rat corresponding to 40% of their body weight ) inhibited to a great extent the benzo(a)pyrene carcinogenesis. Only one slowly growing rhabdomyosarcoma (13 g of weight) was developed showing characteristic damage of malignant cells and partial replacement of the neoplastic area with granuloma tissue. The significance ov Vitamin C for cancer prevention and treatment is discussed.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/BF00411283</identifier><identifier>PMID: 7400211</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; Ascorbic Acid - pharmacology ; Benzopyrenes - toxicity ; Dose-Response Relationship, Drug ; Fibrosarcoma - chemically induced ; Neoplasms, Experimental - chemically induced ; Neoplasms, Experimental - prevention & control ; Rats ; Rhabdomyosarcoma - chemically induced ; Sarcoma, Experimental - chemically induced</subject><ispartof>Journal of cancer research and clinical oncology, 1980-01, Vol.97 (1), p.91-96</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-a1613a3ce09766d86a4c3ebc716c6e437df0d108b4d2a585c3f23ef0ffb76c883</citedby><cites>FETCH-LOGICAL-c282t-a1613a3ce09766d86a4c3ebc716c6e437df0d108b4d2a585c3f23ef0ffb76c883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7400211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kallistratos, G</creatorcontrib><creatorcontrib>Fasske, E</creatorcontrib><title>Inhibition of benzo(a)pyrene carcinogenesis in rats with vitamin C</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><description>The s.c. infection of 10 mg benzo(a)pyrene dissolved in 1 ml tricaprylin induced in Wistar rats local malignant tumors, such as fibrosarcoma, rhabdomyosarcoma, and polymorph cell sarcoma. The growth of the tumors was relatively rapid, reaching weights of 140-155 g before rats died 142-168 days after the administration of the carcinogen. On the contrary, under the same experimental conditions, high doses of Vitamin C about 525 mg/day/rat administered orally in drinking water (total amount of Vitamin C 55 g/rat corresponding to 40% of their body weight ) inhibited to a great extent the benzo(a)pyrene carcinogenesis. Only one slowly growing rhabdomyosarcoma (13 g of weight) was developed showing characteristic damage of malignant cells and partial replacement of the neoplastic area with granuloma tissue. The significance ov Vitamin C for cancer prevention and treatment is discussed.</description><subject>Animals</subject><subject>Ascorbic Acid - pharmacology</subject><subject>Benzopyrenes - toxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fibrosarcoma - chemically induced</subject><subject>Neoplasms, Experimental - chemically induced</subject><subject>Neoplasms, Experimental - prevention & control</subject><subject>Rats</subject><subject>Rhabdomyosarcoma - chemically induced</subject><subject>Sarcoma, Experimental - chemically induced</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUh4Mos04v3oUcVai-l7RJPLridDDwoueSpImL2HYk1TH_eisbenq_9-PjwfsIOUe4QQB5O5sDFIhM8QOSYcFZjpyXhyQDlJiXDMUxOUnpHca9lGxCJrIAYIgZmS26VTBhCH1He0-N6777S3213kbXOWp1tKHr38acQqKho1EPiW7CsKJfYdDt2FSn5Mjrj-TO9nNKXucPL9VTvnx-XFT3y9wyxYZco0CuuXVwJ4VolNCF5c5YicIKV3DZeGgQlCkapktVWu4Zdx68N1JYpfiUXO_u2tinFJ2v1zG0Om5rhPrXQ_3vYYQvdvD607Su-UP3j_MfNaVXNw</recordid><startdate>19800101</startdate><enddate>19800101</enddate><creator>Kallistratos, G</creator><creator>Fasske, E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19800101</creationdate><title>Inhibition of benzo(a)pyrene carcinogenesis in rats with vitamin C</title><author>Kallistratos, G ; Fasske, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-a1613a3ce09766d86a4c3ebc716c6e437df0d108b4d2a585c3f23ef0ffb76c883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Ascorbic Acid - pharmacology</topic><topic>Benzopyrenes - toxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fibrosarcoma - chemically induced</topic><topic>Neoplasms, Experimental - chemically induced</topic><topic>Neoplasms, Experimental - prevention & control</topic><topic>Rats</topic><topic>Rhabdomyosarcoma - chemically induced</topic><topic>Sarcoma, Experimental - chemically induced</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kallistratos, G</creatorcontrib><creatorcontrib>Fasske, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kallistratos, G</au><au>Fasske, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of benzo(a)pyrene carcinogenesis in rats with vitamin C</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>1980-01-01</date><risdate>1980</risdate><volume>97</volume><issue>1</issue><spage>91</spage><epage>96</epage><pages>91-96</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>The s.c. infection of 10 mg benzo(a)pyrene dissolved in 1 ml tricaprylin induced in Wistar rats local malignant tumors, such as fibrosarcoma, rhabdomyosarcoma, and polymorph cell sarcoma. 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| ispartof | Journal of cancer research and clinical oncology, 1980-01, Vol.97 (1), p.91-96 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00411283 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Ascorbic Acid - pharmacology Benzopyrenes - toxicity Dose-Response Relationship, Drug Fibrosarcoma - chemically induced Neoplasms, Experimental - chemically induced Neoplasms, Experimental - prevention & control Rats Rhabdomyosarcoma - chemically induced Sarcoma, Experimental - chemically induced |
| title | Inhibition of benzo(a)pyrene carcinogenesis in rats with vitamin C |
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