The toxicity of non-ionic water-soluble monomeric and dimeric contrast media in selective vertebral angiography. An experimental study in rabbits
Selective vertebral angiography was performed in 29 rabbits in order to compare the adverse effects of three monomeric (iopamidol, iopromide, metrizamide) and one dimeric (iodecol) non-ionic water-soluble contrast medium. The dose was 10 ml and the iodine concentration 350 mg/ml. Marked, but transit...
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| Veröffentlicht in: | Neuroradiology 1983-01, Vol.24 (4), p.219-223 |
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| creator | Skalpe, I O |
| description | Selective vertebral angiography was performed in 29 rabbits in order to compare the adverse effects of three monomeric (iopamidol, iopromide, metrizamide) and one dimeric (iodecol) non-ionic water-soluble contrast medium. The dose was 10 ml and the iodine concentration 350 mg/ml. Marked, but transitory changes were seen in the electrocardiographic and blood pressure recordings with all the contrast media. The monomers seemed to have a higher tendency than the dimer to cause spasm in the intracranial arteries, while the changes in the cardiovascular recordings were more marked with the dimer. One animal died and one animal developed a permanent neurological deficit following the injection of the dimer. All the other animals recovered completely and seemed quite unaffected within half an hour after completion of the experiment. |
| doi_str_mv | 10.1007/BF00399775 |
| format | Article |
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All the other animals recovered completely and seemed quite unaffected within half an hour after completion of the experiment.</description><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Contrast Media - adverse effects</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Iopamidol</subject><subject>Iothalamic Acid - adverse effects</subject><subject>Iothalamic Acid - analogs & derivatives</subject><subject>Male</subject><subject>Metrizamide - adverse effects</subject><subject>Pulse - drug effects</subject><subject>Rabbits</subject><subject>Radiography</subject><subject>Vertebral Artery - diagnostic imaging</subject><issn>0028-3940</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFPAjEQhRujQUQv3k16Nlnstrvb9ohE1ITEC55JtzsLNbstaQvCz_AfWwLR00xmvjd58xC6z8k4J4Q_Pc8IYVJyXl6gYV4wmuWSkks0JISKjMmCXKObEL5IwjjjAzSoBBWUiSH6WawBR7c32sQDdi22zmbGWaPxt4rgs-C6bd0B7p11Pfg0V7bBjTn12tnoVYi4h8YobCwO0IGOZgd4Bz5C7VWXFCvjVl5t1ocxnlgM-01S92BjWoa4bQ5HpVd1bWK4RVet6gLcnesIfc5eFtO3bP7x-j6dzDNNizxmJS1KVhFaFloXJZegNBVakZYU0LSyaKCSbZmoSjaSCs6YrIlQQLXgmlPBRujxdFd7F4KHdrlJnpQ_LHOyPMa6_I81wQ8neLOt06t_6DlH9gugFXTi</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Skalpe, I O</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19830101</creationdate><title>The toxicity of non-ionic water-soluble monomeric and dimeric contrast media in selective vertebral angiography. An experimental study in rabbits</title><author>Skalpe, I O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-5245360254cc4579eac28ca0f04edf94de69f552469d9287339b08ae2c87c7283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Contrast Media - adverse effects</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Iopamidol</topic><topic>Iothalamic Acid - adverse effects</topic><topic>Iothalamic Acid - analogs & derivatives</topic><topic>Male</topic><topic>Metrizamide - adverse effects</topic><topic>Pulse - drug effects</topic><topic>Rabbits</topic><topic>Radiography</topic><topic>Vertebral Artery - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skalpe, I O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skalpe, I O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The toxicity of non-ionic water-soluble monomeric and dimeric contrast media in selective vertebral angiography. 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One animal died and one animal developed a permanent neurological deficit following the injection of the dimer. All the other animals recovered completely and seemed quite unaffected within half an hour after completion of the experiment.</abstract><cop>Germany</cop><pmid>6828238</pmid><doi>10.1007/BF00399775</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-3940 |
| ispartof | Neuroradiology, 1983-01, Vol.24 (4), p.219-223 |
| issn | 0028-3940 1432-1920 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00399775 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Blood Pressure - drug effects Chemical Phenomena Chemistry Contrast Media - adverse effects Electrocardiography Female Iopamidol Iothalamic Acid - adverse effects Iothalamic Acid - analogs & derivatives Male Metrizamide - adverse effects Pulse - drug effects Rabbits Radiography Vertebral Artery - diagnostic imaging |
| title | The toxicity of non-ionic water-soluble monomeric and dimeric contrast media in selective vertebral angiography. An experimental study in rabbits |
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