Fever response of sheep in the peripartum period to Gram-negative and Gram-positive pyrogens
We have measured body temperatures and serum iron concentrations of sheep in the peripartum period following administration of endotoxin and Staphylococcus aureus cell walls. Both the rise in rectal temperature and the fall in serum iron concentration following intravenous injection of S. aureus wer...
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| Veröffentlicht in: | Pflügers Archiv 1992-03, Vol.420 (3-4), p.259-263 |
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| container_title | Pflügers Archiv |
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| creator | GOELST, K MITCHELL, D MACPHAIL, A. P COOPER, K. E LABURN, H |
| description | We have measured body temperatures and serum iron concentrations of sheep in the peripartum period following administration of endotoxin and Staphylococcus aureus cell walls. Both the rise in rectal temperature and the fall in serum iron concentration following intravenous injection of S. aureus were the same immediately pre- and postpartum as they were 5 weeks after parturition. The rise in rectal temperature following intravenous endotoxin injection immediately pre- and postpartum was significantly less than that of the same ewes 5 weeks later. However, the fall in serum iron concentration following endotoxin injection was significantly suppressed only prepartum. We conclude that fever is not suppressed in sheep in the peripartum period, but the response to endotoxin is suppressed, through complex processes incidental to the mechanism responsible for the maintenance of gestation and induction of labour. |
| doi_str_mv | 10.1007/BF00374456 |
| format | Article |
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We conclude that fever is not suppressed in sheep in the peripartum period, but the response to endotoxin is suppressed, through complex processes incidental to the mechanism responsible for the maintenance of gestation and induction of labour.</description><identifier>ISSN: 0031-6768</identifier><identifier>EISSN: 1432-2013</identifier><identifier>DOI: 10.1007/BF00374456</identifier><identifier>PMID: 1598182</identifier><identifier>CODEN: PFLABK</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Bacterial Toxins - pharmacology ; Bacteriology ; Biological and medical sciences ; Body Temperature ; Cell Wall - physiology ; Endotoxins - pharmacology ; Enterotoxins - pharmacology ; Female ; Fever - microbiology ; Fundamental and applied biological sciences. 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P</creatorcontrib><creatorcontrib>COOPER, K. E</creatorcontrib><creatorcontrib>LABURN, H</creatorcontrib><title>Fever response of sheep in the peripartum period to Gram-negative and Gram-positive pyrogens</title><title>Pflügers Archiv</title><addtitle>Pflugers Arch</addtitle><description>We have measured body temperatures and serum iron concentrations of sheep in the peripartum period following administration of endotoxin and Staphylococcus aureus cell walls. Both the rise in rectal temperature and the fall in serum iron concentration following intravenous injection of S. aureus were the same immediately pre- and postpartum as they were 5 weeks after parturition. The rise in rectal temperature following intravenous endotoxin injection immediately pre- and postpartum was significantly less than that of the same ewes 5 weeks later. However, the fall in serum iron concentration following endotoxin injection was significantly suppressed only prepartum. We conclude that fever is not suppressed in sheep in the peripartum period, but the response to endotoxin is suppressed, through complex processes incidental to the mechanism responsible for the maintenance of gestation and induction of labour.</description><subject>Animals</subject><subject>Bacterial Toxins - pharmacology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Body Temperature</subject><subject>Cell Wall - physiology</subject><subject>Endotoxins - pharmacology</subject><subject>Enterotoxins - pharmacology</subject><subject>Female</subject><subject>Fever - microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Iron - blood</subject><subject>Microbiology</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Postpartum Period</subject><subject>Pregnancy</subject><subject>Pyrogens - pharmacology</subject><subject>Sheep</subject><subject>Staphylococcus aureus - physiology</subject><issn>0031-6768</issn><issn>1432-2013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUxoMoc04v3oUcPAnVvCRt06MON4WBF70JJU1etsrahqQb7L93rsOd3sfv-_EOHyG3wB6BsfzpZcaYyKVMszMyBil4whmIczLeY0iyPFOX5CrGH8YYl4qPyAjSQoHiY_I9wy0GGjD6ro1IO0fjCtHTuqX9CqnHUHsd-k1ziJ2lfUfnQTdJi0vd11ukurUD8V2sD8TvQrfENl6TC6fXEW-Od0K-Zq-f07dk8TF_nz4vEiMA-sRwxwV3rAJunLYFMFsYCbnUAFVqeJE5sFbJyqDlyhiUmKncKiOcU05nYkIehr8mdDEGdKUPdaPDrgRW_i1Unhbay3eD7DdVg_akDpPs-_tjr6PRaxd0a-r4r6U8V1Iq8Qu6dW6e</recordid><startdate>19920301</startdate><enddate>19920301</enddate><creator>GOELST, K</creator><creator>MITCHELL, D</creator><creator>MACPHAIL, A. 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Psychology</topic><topic>Iron - blood</topic><topic>Microbiology</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Postpartum Period</topic><topic>Pregnancy</topic><topic>Pyrogens - pharmacology</topic><topic>Sheep</topic><topic>Staphylococcus aureus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOELST, K</creatorcontrib><creatorcontrib>MITCHELL, D</creatorcontrib><creatorcontrib>MACPHAIL, A. P</creatorcontrib><creatorcontrib>COOPER, K. 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E</au><au>LABURN, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fever response of sheep in the peripartum period to Gram-negative and Gram-positive pyrogens</atitle><jtitle>Pflügers Archiv</jtitle><addtitle>Pflugers Arch</addtitle><date>1992-03-01</date><risdate>1992</risdate><volume>420</volume><issue>3-4</issue><spage>259</spage><epage>263</epage><pages>259-263</pages><issn>0031-6768</issn><eissn>1432-2013</eissn><coden>PFLABK</coden><abstract>We have measured body temperatures and serum iron concentrations of sheep in the peripartum period following administration of endotoxin and Staphylococcus aureus cell walls. Both the rise in rectal temperature and the fall in serum iron concentration following intravenous injection of S. aureus were the same immediately pre- and postpartum as they were 5 weeks after parturition. The rise in rectal temperature following intravenous endotoxin injection immediately pre- and postpartum was significantly less than that of the same ewes 5 weeks later. However, the fall in serum iron concentration following endotoxin injection was significantly suppressed only prepartum. We conclude that fever is not suppressed in sheep in the peripartum period, but the response to endotoxin is suppressed, through complex processes incidental to the mechanism responsible for the maintenance of gestation and induction of labour.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>1598182</pmid><doi>10.1007/BF00374456</doi><tpages>5</tpages></addata></record> |
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| ispartof | Pflügers Archiv, 1992-03, Vol.420 (3-4), p.259-263 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Bacterial Toxins - pharmacology Bacteriology Biological and medical sciences Body Temperature Cell Wall - physiology Endotoxins - pharmacology Enterotoxins - pharmacology Female Fever - microbiology Fundamental and applied biological sciences. Psychology Iron - blood Microbiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Postpartum Period Pregnancy Pyrogens - pharmacology Sheep Staphylococcus aureus - physiology |
| title | Fever response of sheep in the peripartum period to Gram-negative and Gram-positive pyrogens |
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