Stereometabolism of styrene in man: gas chromatographic determination of phenylethyleneglycol enantiomers and phenylethanol isomers in the urine of occupationally-exposed persons
A gas chromatographic procedure for the determination of phenylethyleneglycol enantiomers and phenylethanol isomers is described and applied to the investigation of urine samples from occupationally styrene-exposed workers (11 males, six females) and an unexposed control group. Phenylethyleneglycol...
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| Veröffentlicht in: | Archives of toxicology 1985-12, Vol.58 (2), p.110-114 |
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| container_end_page | 114 |
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| container_issue | 2 |
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| container_title | Archives of toxicology |
| container_volume | 58 |
| creator | KORN, M WODARZ, R DRYSCH, K SCHOKNECHT, W SCHMAHL, F. W |
| description | A gas chromatographic procedure for the determination of phenylethyleneglycol enantiomers and phenylethanol isomers is described and applied to the investigation of urine samples from occupationally styrene-exposed workers (11 males, six females) and an unexposed control group. Phenylethyleneglycol enantiomers and 2-phenylethanol were present in the urine samples of exposed and unexposed individuals whereas 1-DL-phenylethanol was not found in control urine. The L/D enantiomer ratio of phenylethyleneglycol was found to be approximately 3 in the exposed group and 1.5 in the control group. Because of the close structural relation of these metabolites to the primarily formed epoxide, the results give further insight into the stereotoxicity of styrene in man. |
| doi_str_mv | 10.1007/BF00348319 |
| format | Article |
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Because of the close structural relation of these metabolites to the primarily formed epoxide, the results give further insight into the stereotoxicity of styrene in man.</description><identifier>ISSN: 0340-5761</identifier><identifier>EISSN: 1432-0738</identifier><identifier>DOI: 10.1007/BF00348319</identifier><identifier>PMID: 2418806</identifier><identifier>CODEN: ARTODN</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. 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W</creatorcontrib><title>Stereometabolism of styrene in man: gas chromatographic determination of phenylethyleneglycol enantiomers and phenylethanol isomers in the urine of occupationally-exposed persons</title><title>Archives of toxicology</title><addtitle>Arch Toxicol</addtitle><description>A gas chromatographic procedure for the determination of phenylethyleneglycol enantiomers and phenylethanol isomers is described and applied to the investigation of urine samples from occupationally styrene-exposed workers (11 males, six females) and an unexposed control group. Phenylethyleneglycol enantiomers and 2-phenylethanol were present in the urine samples of exposed and unexposed individuals whereas 1-DL-phenylethanol was not found in control urine. The L/D enantiomer ratio of phenylethyleneglycol was found to be approximately 3 in the exposed group and 1.5 in the control group. Because of the close structural relation of these metabolites to the primarily formed epoxide, the results give further insight into the stereotoxicity of styrene in man.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chromatography, Gas</subject><subject>Environmental Exposure</subject><subject>Ethanol - analogs & derivatives</subject><subject>Ethylene Glycols - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Occupations</subject><subject>Phenylethyl Alcohol - urine</subject><subject>Rats</subject><subject>Solvents</subject><subject>Stereoisomerism</subject><subject>Styrene</subject><subject>Styrenes - metabolism</subject><subject>Styrenes - toxicity</subject><subject>Toxicology</subject><issn>0340-5761</issn><issn>1432-0738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE9LxDAQxYMouq5evAs5eBKq-dOmrTddXBUED-q5zKbTbaRNStIF-7X8hEZ30csMzPu9N_AIOePsijOWX98tGZNpIXm5R2Y8lSJhuSz2ySxeWZLlih-R4xA-GOOiKOUhORQpLwqmZuTrdUSPrscRVq4zoaeuoWGcPFqkxtIe7A1dQ6C69a6H0a09DK3RtMZo7I2F0Tj7YxpatFOHYxuHxXU3addRtGAj0KMPFGz9D4GNqglbJf4ZW6Qbb-LTGOW03gy_wdB1U4KfgwsYzZF1NpyQgwa6gKe7PSfvy_u3xWPy_PLwtLh9TrTkfExQ5LIWaVnkogRdizITUohCZapsZMZBl6JJV1KmCnKWCwmlRp5qlCvFGg5czsnlNld7F4LHphq86cFPFWfVT-_Vf-8RPt_Cw2bVY_2H7oqO-sVOh6ChazxYbcIfViilZMbkN4U3j04</recordid><startdate>198512</startdate><enddate>198512</enddate><creator>KORN, M</creator><creator>WODARZ, R</creator><creator>DRYSCH, K</creator><creator>SCHOKNECHT, W</creator><creator>SCHMAHL, F. 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Toxic occupational diseases</topic><topic>Chromatography, Gas</topic><topic>Environmental Exposure</topic><topic>Ethanol - analogs & derivatives</topic><topic>Ethylene Glycols - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Occupations</topic><topic>Phenylethyl Alcohol - urine</topic><topic>Rats</topic><topic>Solvents</topic><topic>Stereoisomerism</topic><topic>Styrene</topic><topic>Styrenes - metabolism</topic><topic>Styrenes - toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KORN, M</creatorcontrib><creatorcontrib>WODARZ, R</creatorcontrib><creatorcontrib>DRYSCH, K</creatorcontrib><creatorcontrib>SCHOKNECHT, W</creatorcontrib><creatorcontrib>SCHMAHL, F. 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W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stereometabolism of styrene in man: gas chromatographic determination of phenylethyleneglycol enantiomers and phenylethanol isomers in the urine of occupationally-exposed persons</atitle><jtitle>Archives of toxicology</jtitle><addtitle>Arch Toxicol</addtitle><date>1985-12</date><risdate>1985</risdate><volume>58</volume><issue>2</issue><spage>110</spage><epage>114</epage><pages>110-114</pages><issn>0340-5761</issn><eissn>1432-0738</eissn><coden>ARTODN</coden><abstract>A gas chromatographic procedure for the determination of phenylethyleneglycol enantiomers and phenylethanol isomers is described and applied to the investigation of urine samples from occupationally styrene-exposed workers (11 males, six females) and an unexposed control group. Phenylethyleneglycol enantiomers and 2-phenylethanol were present in the urine samples of exposed and unexposed individuals whereas 1-DL-phenylethanol was not found in control urine. The L/D enantiomer ratio of phenylethyleneglycol was found to be approximately 3 in the exposed group and 1.5 in the control group. Because of the close structural relation of these metabolites to the primarily formed epoxide, the results give further insight into the stereotoxicity of styrene in man.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2418806</pmid><doi>10.1007/BF00348319</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-5761 |
| ispartof | Archives of toxicology, 1985-12, Vol.58 (2), p.110-114 |
| issn | 0340-5761 1432-0738 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00348319 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chromatography, Gas Environmental Exposure Ethanol - analogs & derivatives Ethylene Glycols - urine Female Humans Male Medical sciences Occupations Phenylethyl Alcohol - urine Rats Solvents Stereoisomerism Styrene Styrenes - metabolism Styrenes - toxicity Toxicology |
| title | Stereometabolism of styrene in man: gas chromatographic determination of phenylethyleneglycol enantiomers and phenylethanol isomers in the urine of occupationally-exposed persons |
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