On the activity of brain phospholipase A2 towards specifically labelled glycerophospholipids during subacute sclerosing panencephalitis
1,2-Diacyl-sn-glycero-3-phosphorylcholine, -ethanolamine and -serine, specifically labelled with different fatty acids at either the 1- or 2-position, were prepared enzymatically using the acyltransferase system of rat liver microsomes. The substrates were subjected to hydrolysis by phospholipase A2...
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| Veröffentlicht in: | Archiv f r Psychiatrie und Nervenkrankheiten 1975-01, Vol.220 (2), p.131-137 |
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| container_end_page | 137 |
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| container_issue | 2 |
| container_start_page | 131 |
| container_title | Archiv f r Psychiatrie und Nervenkrankheiten |
| container_volume | 220 |
| creator | Jakumeit-Morgott, U Woelk, H Kanig, K |
| description | 1,2-Diacyl-sn-glycero-3-phosphorylcholine, -ethanolamine and -serine, specifically labelled with different fatty acids at either the 1- or 2-position, were prepared enzymatically using the acyltransferase system of rat liver microsomes. The substrates were subjected to hydrolysis by phospholipase A2 obtained from brain tissue of a normal and a case of subacute sclerosing panencephalitis (SSPE). In the pathological tissue and increase of approx. 50% in phospholipase A2 activity could be observed in comparison to that from the control brain for all investigated substrates. Experiments with phosphatidylethanolamines, specifically labelled with different fatty acids in the 2-position, revealed that the phospholipase A2 activity of the SSPE brain tissue was enhanced by about 50% when compared to the control brain regardless of the fatty acid constituent at the 2-position of the substrates. |
| doi_str_mv | 10.1007/BF00341646 |
| format | Article |
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The substrates were subjected to hydrolysis by phospholipase A2 obtained from brain tissue of a normal and a case of subacute sclerosing panencephalitis (SSPE). In the pathological tissue and increase of approx. 50% in phospholipase A2 activity could be observed in comparison to that from the control brain for all investigated substrates. Experiments with phosphatidylethanolamines, specifically labelled with different fatty acids in the 2-position, revealed that the phospholipase A2 activity of the SSPE brain tissue was enhanced by about 50% when compared to the control brain regardless of the fatty acid constituent at the 2-position of the substrates.</description><identifier>ISSN: 0003-9373</identifier><identifier>EISSN: 1433-8491</identifier><identifier>DOI: 10.1007/BF00341646</identifier><identifier>PMID: 1180685</identifier><language>eng</language><publisher>Germany</publisher><subject>Adolescent ; Cerebral Cortex - enzymology ; Humans ; Male ; Microsomes - enzymology ; Mitochondria - enzymology ; Phosphatidylcholines - metabolism ; Phosphatidylethanolamines - metabolism ; Phosphatidylglycerols - metabolism ; Phosphatidylserines - metabolism ; Phospholipases - metabolism ; Phospholipids - metabolism ; Subacute Sclerosing Panencephalitis - enzymology ; Time Factors</subject><ispartof>Archiv f r Psychiatrie und Nervenkrankheiten, 1975-01, Vol.220 (2), p.131-137</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c251t-bcac993141e239e2e35a41e063df88de3ea04f5e0d708b7de85f3b196cb52ffd3</citedby><cites>FETCH-LOGICAL-c251t-bcac993141e239e2e35a41e063df88de3ea04f5e0d708b7de85f3b196cb52ffd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1180685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jakumeit-Morgott, U</creatorcontrib><creatorcontrib>Woelk, H</creatorcontrib><creatorcontrib>Kanig, K</creatorcontrib><title>On the activity of brain phospholipase A2 towards specifically labelled glycerophospholipids during subacute sclerosing panencephalitis</title><title>Archiv f r Psychiatrie und Nervenkrankheiten</title><addtitle>Arch Psychiatr Nervenkr (1970)</addtitle><description>1,2-Diacyl-sn-glycero-3-phosphorylcholine, -ethanolamine and -serine, specifically labelled with different fatty acids at either the 1- or 2-position, were prepared enzymatically using the acyltransferase system of rat liver microsomes. 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| fulltext | fulltext |
| identifier | ISSN: 0003-9373 |
| ispartof | Archiv f r Psychiatrie und Nervenkrankheiten, 1975-01, Vol.220 (2), p.131-137 |
| issn | 0003-9373 1433-8491 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00341646 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Cerebral Cortex - enzymology Humans Male Microsomes - enzymology Mitochondria - enzymology Phosphatidylcholines - metabolism Phosphatidylethanolamines - metabolism Phosphatidylglycerols - metabolism Phosphatidylserines - metabolism Phospholipases - metabolism Phospholipids - metabolism Subacute Sclerosing Panencephalitis - enzymology Time Factors |
| title | On the activity of brain phospholipase A2 towards specifically labelled glycerophospholipids during subacute sclerosing panencephalitis |
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