Enhancement of spontaneous and lymphokine activated human macrophage cytotoxicity by hyperthermia
Human macrophages grown on hydrophobic teflon membranes from blood-born monocytes were incubated at hyperthermic temperatures for various time periods and then tested for their ability to inhibit the growth of an allogeneic lymphoma cell line (U 937). Incubation at 40.5 degrees C greatly enhanced ma...
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| Veröffentlicht in: | Blut 1983-10, Vol.47 (4), p.225-229 |
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| creator | ANDREESEN, R OSTERHOLZ, J SCHULZ, A LOHR, G. W |
| description | Human macrophages grown on hydrophobic teflon membranes from blood-born monocytes were incubated at hyperthermic temperatures for various time periods and then tested for their ability to inhibit the growth of an allogeneic lymphoma cell line (U 937). Incubation at 40.5 degrees C greatly enhanced macrophage cytotoxicity. This effect of hyperthermia developed slowly with an optimal incubation period of 48 h. In addition, lymphokine activation of macrophages for cytotoxicity appeared to be more effective at elevated temperatures. |
| doi_str_mv | 10.1007/bf00320841 |
| format | Article |
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Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Hyperthermia, Induced</subject><subject>Immunobiology</subject><subject>Lymphokines - pharmacology</subject><subject>Lymphoma - immunology</subject><subject>Macrophages - immunology</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><issn>0006-5242</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtLxEAUhQdR1nW1sRemEAsheueRmaTUZVeFBRutw81kYqJ5mZmI-fdm2dVWbnGL83HgfIScM7hhAPo2zQEEh0iyAzJnUvAAwkgekjkAqCDkkh-TE-feAULBIz0jM6WYAi3mBFdNgY2xtW08bXPqurbx2Nh2cBSbjFZj3RXtR9lYisaXX-htRouhxobWaPq2K_DNUjP61rffpSn9SNORFmNne1_Yvi7xlBzlWDl7tv8L8rpevSwfg83zw9PybhMYwYUPWJ6HPNQmxlAAIk9NqHKWxgzN9iQTWiGTUkng3AileWxTkUqjM5YxMGJBrna9Xd9-Dtb5pC6dsVW1W5NEoEIRa_EvyOSkUICawOsdOO10rrd50vVljf2YMEi24pP79a_4Cb7Ytw5pbbM_dG96yi_3OTqDVd5P1kv3h8XTskhq8QPNvouk</recordid><startdate>198310</startdate><enddate>198310</enddate><creator>ANDREESEN, R</creator><creator>OSTERHOLZ, J</creator><creator>SCHULZ, A</creator><creator>LOHR, G. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Hyperthermia, Induced</topic><topic>Immunobiology</topic><topic>Lymphokines - pharmacology</topic><topic>Lymphoma - immunology</topic><topic>Macrophages - immunology</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ANDREESEN, R</creatorcontrib><creatorcontrib>OSTERHOLZ, J</creatorcontrib><creatorcontrib>SCHULZ, A</creatorcontrib><creatorcontrib>LOHR, G. 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| ispartof | Blut, 1983-10, Vol.47 (4), p.225-229 |
| issn | 0006-5242 1432-0584 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00320841 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biological and medical sciences Cell Line Cells, Cultured Cytotoxicity, Immunologic - drug effects Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hyperthermia, Induced Immunobiology Lymphokines - pharmacology Lymphoma - immunology Macrophages - immunology Modulation of the immune response (stimulation, suppression) |
| title | Enhancement of spontaneous and lymphokine activated human macrophage cytotoxicity by hyperthermia |
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