Influence of midazolam on the plasma concentrations of mepivacaine after lumbar epidural injection in children

Twenty children undergoing surgery received a lumbar block using 0.4 ml/kg mepivacaine 2.0%. They were randomized into two groups, one of which received midazolam 0.4 mg/kg rectally as premedication. Midazolam administration did not significantly influence the plasma concentrations of mepivacaine.

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Bibliographische Detailangaben
Veröffentlicht in:	European journal of clinical pharmacology 1990, Vol.38 (1), p.91-92
Hauptverfasser:	GIAUFRE, E, BRUGUEROLLE, B, MORISSON-LACOMBE, G, ROUSSET-ROUVIERE, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anesthesia, Epidural Anesthetics. Neuromuscular blocking agents Biological and medical sciences Child Child, Preschool Drug Interactions Humans Male Medical sciences Mepivacaine - administration & dosage Mepivacaine - blood Mepivacaine - pharmacokinetics Midazolam - pharmacology Neuropharmacology Pharmacology. Drug treatments Preanesthetic Medication Random Allocation
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Beschreibung
Zusammenfassung:	Twenty children undergoing surgery received a lumbar block using 0.4 ml/kg mepivacaine 2.0%. They were randomized into two groups, one of which received midazolam 0.4 mg/kg rectally as premedication. Midazolam administration did not significantly influence the plasma concentrations of mepivacaine.
ISSN:	0031-6970 1432-1041
DOI:	10.1007/BF00314812