Effect of verapamil on daunorubicin accumulation in Ehrlich ascites tumor cells

Previous studies have demonstrated that verapamil may overcome resistance to anthracyclines. In vitro and in vivo experiments were performed on wild-type and resistant Ehrlich ascites tumor cells. Verapamil in concentrations of 25-50 microM enhances the accumulation of daunorubicin (DNR) in resistan...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1987-01, Vol.19 (1), p.35-39
Hauptverfasser:	FRICHE, E, SKOVSGAARD, T, NISSEN, N. I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Biological Transport, Active - drug effects Calcium - pharmacology Carcinoma, Ehrlich Tumor - metabolism Carcinoma, Ehrlich Tumor - pathology Cell Line Daunorubicin - metabolism Daunorubicin - toxicity Dose-Response Relationship, Drug Drug Resistance Drug Synergism Female General aspects Glucose - pharmacology Medical sciences Mice Mice, Inbred Strains Pharmacology. Drug treatments Stimulation, Chemical Verapamil - pharmacology Verapamil - toxicity
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