Testicular atrophy induced by di(2-ethylhexyl)phthalate: changes in histology, cell specific enzyme activities and zinc concentrations in rat testis
Daily administration of 2g/kg/day di(2-ethylhexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase a...
Gespeichert in:
| Veröffentlicht in: | Archives of toxicology 1986-12, Vol.59 (4), p.290-295 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 295 |
|---|---|
| container_issue | 4 |
| container_start_page | 290 |
| container_title | Archives of toxicology |
| container_volume | 59 |
| creator | Oishi, S |
| description | Daily administration of 2g/kg/day di(2-ethylhexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase and sorbitol dehydrogenase, were lower than those of control by day 10, coincident with degeneration of spermatogenic cells. The specific activities of enzymes associated with premeiotic spermatogenic cells, Sertoli cells or interstitial cells (beta-glucuronidase, gamma-glutamyl transpeptidase and malate dehydrogenase) were higher than those of control by day 10. The specific activities of alcohol dehydrogenase and aldolase, zinc containing enzymes, increased after DEHP treatment in spite of the decrease in zinc concentration in the testis. In conclusion, changes in several testicular cell-specific enzymes appear to be useful biochemical markers of testicular injury induced by testicular toxicants such as DEHP. However, these changes occurred after or simultaneous with massive histological or morphological changes rather than prior to such changes. |
| doi_str_mv | 10.1007/bf00290553 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF00290553</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2881530</sourcerecordid><originalsourceid>FETCH-LOGICAL-c348t-9cc15fb6ec3dad1ce3ed0367243ab4a158a714b113cf0024a0de9842b9dbc2573</originalsourceid><addsrcrecordid>eNo9kLFOwzAURS0EKqWwsCN5BETAjp0mYYOKAlIlljJXzvNLY-Q6Uewi0u_gg0lpYbp3OLq6OoScc3bLGUvvipKxOGdJIg7IkEsRRywV2SEZMiFZlKRjfkxOvP9gjMdZLgZkEGcZTwQbku85-mBgbVVLVWjrpuqocXoNqGnRUW0u4whD1dkKvzp71VShUlYFvKdQKbdE39O0Mj7Utl52NxTQWuobBFMaoOg23QqpgmA-TTA9rZymG-OAQu0AXWhVMLX7XekrDds3_pQclcp6PNvniLxPn-aTl2j29vw6eZhFIGQWohyAJ2UxRhBaaQ4oUDMxTmMpVCEVTzKVcllwLmArSCqmMc9kXOS6gDhJxYhc73ahrb1vsVw0rVmptltwttiaXTxO_8z28MUObtbFCvU_ulcpfgABw3cm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Testicular atrophy induced by di(2-ethylhexyl)phthalate: changes in histology, cell specific enzyme activities and zinc concentrations in rat testis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Oishi, S</creator><creatorcontrib>Oishi, S</creatorcontrib><description>Daily administration of 2g/kg/day di(2-ethylhexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase and sorbitol dehydrogenase, were lower than those of control by day 10, coincident with degeneration of spermatogenic cells. The specific activities of enzymes associated with premeiotic spermatogenic cells, Sertoli cells or interstitial cells (beta-glucuronidase, gamma-glutamyl transpeptidase and malate dehydrogenase) were higher than those of control by day 10. The specific activities of alcohol dehydrogenase and aldolase, zinc containing enzymes, increased after DEHP treatment in spite of the decrease in zinc concentration in the testis. In conclusion, changes in several testicular cell-specific enzymes appear to be useful biochemical markers of testicular injury induced by testicular toxicants such as DEHP. However, these changes occurred after or simultaneous with massive histological or morphological changes rather than prior to such changes.</description><identifier>ISSN: 0340-5761</identifier><identifier>EISSN: 1432-0738</identifier><identifier>DOI: 10.1007/bf00290553</identifier><identifier>PMID: 2881530</identifier><language>eng</language><publisher>Germany</publisher><subject>Alcohol Oxidoreductases - metabolism ; Animals ; Atrophy - chemically induced ; Diethylhexyl Phthalate - toxicity ; gamma-Glutamyltransferase - metabolism ; Glucuronidase - metabolism ; Lyases - metabolism ; Male ; Organ Size - drug effects ; Phthalic Acids - toxicity ; Rats ; Rats, Inbred Strains ; Spermatogenesis - drug effects ; Testis - drug effects ; Testis - enzymology ; Testis - pathology ; Zinc - metabolism</subject><ispartof>Archives of toxicology, 1986-12, Vol.59 (4), p.290-295</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-9cc15fb6ec3dad1ce3ed0367243ab4a158a714b113cf0024a0de9842b9dbc2573</citedby><cites>FETCH-LOGICAL-c348t-9cc15fb6ec3dad1ce3ed0367243ab4a158a714b113cf0024a0de9842b9dbc2573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2881530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oishi, S</creatorcontrib><title>Testicular atrophy induced by di(2-ethylhexyl)phthalate: changes in histology, cell specific enzyme activities and zinc concentrations in rat testis</title><title>Archives of toxicology</title><addtitle>Arch Toxicol</addtitle><description>Daily administration of 2g/kg/day di(2-ethylhexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase and sorbitol dehydrogenase, were lower than those of control by day 10, coincident with degeneration of spermatogenic cells. The specific activities of enzymes associated with premeiotic spermatogenic cells, Sertoli cells or interstitial cells (beta-glucuronidase, gamma-glutamyl transpeptidase and malate dehydrogenase) were higher than those of control by day 10. The specific activities of alcohol dehydrogenase and aldolase, zinc containing enzymes, increased after DEHP treatment in spite of the decrease in zinc concentration in the testis. In conclusion, changes in several testicular cell-specific enzymes appear to be useful biochemical markers of testicular injury induced by testicular toxicants such as DEHP. However, these changes occurred after or simultaneous with massive histological or morphological changes rather than prior to such changes.</description><subject>Alcohol Oxidoreductases - metabolism</subject><subject>Animals</subject><subject>Atrophy - chemically induced</subject><subject>Diethylhexyl Phthalate - toxicity</subject><subject>gamma-Glutamyltransferase - metabolism</subject><subject>Glucuronidase - metabolism</subject><subject>Lyases - metabolism</subject><subject>Male</subject><subject>Organ Size - drug effects</subject><subject>Phthalic Acids - toxicity</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Spermatogenesis - drug effects</subject><subject>Testis - drug effects</subject><subject>Testis - enzymology</subject><subject>Testis - pathology</subject><subject>Zinc - metabolism</subject><issn>0340-5761</issn><issn>1432-0738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kLFOwzAURS0EKqWwsCN5BETAjp0mYYOKAlIlljJXzvNLY-Q6Uewi0u_gg0lpYbp3OLq6OoScc3bLGUvvipKxOGdJIg7IkEsRRywV2SEZMiFZlKRjfkxOvP9gjMdZLgZkEGcZTwQbku85-mBgbVVLVWjrpuqocXoNqGnRUW0u4whD1dkKvzp71VShUlYFvKdQKbdE39O0Mj7Utl52NxTQWuobBFMaoOg23QqpgmA-TTA9rZymG-OAQu0AXWhVMLX7XekrDds3_pQclcp6PNvniLxPn-aTl2j29vw6eZhFIGQWohyAJ2UxRhBaaQ4oUDMxTmMpVCEVTzKVcllwLmArSCqmMc9kXOS6gDhJxYhc73ahrb1vsVw0rVmptltwttiaXTxO_8z28MUObtbFCvU_ulcpfgABw3cm</recordid><startdate>198612</startdate><enddate>198612</enddate><creator>Oishi, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198612</creationdate><title>Testicular atrophy induced by di(2-ethylhexyl)phthalate: changes in histology, cell specific enzyme activities and zinc concentrations in rat testis</title><author>Oishi, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-9cc15fb6ec3dad1ce3ed0367243ab4a158a714b113cf0024a0de9842b9dbc2573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Alcohol Oxidoreductases - metabolism</topic><topic>Animals</topic><topic>Atrophy - chemically induced</topic><topic>Diethylhexyl Phthalate - toxicity</topic><topic>gamma-Glutamyltransferase - metabolism</topic><topic>Glucuronidase - metabolism</topic><topic>Lyases - metabolism</topic><topic>Male</topic><topic>Organ Size - drug effects</topic><topic>Phthalic Acids - toxicity</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Spermatogenesis - drug effects</topic><topic>Testis - drug effects</topic><topic>Testis - enzymology</topic><topic>Testis - pathology</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oishi, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Archives of toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oishi, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testicular atrophy induced by di(2-ethylhexyl)phthalate: changes in histology, cell specific enzyme activities and zinc concentrations in rat testis</atitle><jtitle>Archives of toxicology</jtitle><addtitle>Arch Toxicol</addtitle><date>1986-12</date><risdate>1986</risdate><volume>59</volume><issue>4</issue><spage>290</spage><epage>295</epage><pages>290-295</pages><issn>0340-5761</issn><eissn>1432-0738</eissn><abstract>Daily administration of 2g/kg/day di(2-ethylhexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase and sorbitol dehydrogenase, were lower than those of control by day 10, coincident with degeneration of spermatogenic cells. The specific activities of enzymes associated with premeiotic spermatogenic cells, Sertoli cells or interstitial cells (beta-glucuronidase, gamma-glutamyl transpeptidase and malate dehydrogenase) were higher than those of control by day 10. The specific activities of alcohol dehydrogenase and aldolase, zinc containing enzymes, increased after DEHP treatment in spite of the decrease in zinc concentration in the testis. In conclusion, changes in several testicular cell-specific enzymes appear to be useful biochemical markers of testicular injury induced by testicular toxicants such as DEHP. However, these changes occurred after or simultaneous with massive histological or morphological changes rather than prior to such changes.</abstract><cop>Germany</cop><pmid>2881530</pmid><doi>10.1007/bf00290553</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-5761 |
| ispartof | Archives of toxicology, 1986-12, Vol.59 (4), p.290-295 |
| issn | 0340-5761 1432-0738 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00290553 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Alcohol Oxidoreductases - metabolism Animals Atrophy - chemically induced Diethylhexyl Phthalate - toxicity gamma-Glutamyltransferase - metabolism Glucuronidase - metabolism Lyases - metabolism Male Organ Size - drug effects Phthalic Acids - toxicity Rats Rats, Inbred Strains Spermatogenesis - drug effects Testis - drug effects Testis - enzymology Testis - pathology Zinc - metabolism |
| title | Testicular atrophy induced by di(2-ethylhexyl)phthalate: changes in histology, cell specific enzyme activities and zinc concentrations in rat testis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T10%3A47%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Testicular%20atrophy%20induced%20by%20di(2-ethylhexyl)phthalate:%20changes%20in%20histology,%20cell%20specific%20enzyme%20activities%20and%20zinc%20concentrations%20in%20rat%20testis&rft.jtitle=Archives%20of%20toxicology&rft.au=Oishi,%20S&rft.date=1986-12&rft.volume=59&rft.issue=4&rft.spage=290&rft.epage=295&rft.pages=290-295&rft.issn=0340-5761&rft.eissn=1432-0738&rft_id=info:doi/10.1007/bf00290553&rft_dat=%3Cpubmed_cross%3E2881530%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/2881530&rfr_iscdi=true |