Ciclosporin metabolite pattern in blood and urine of kidney graft patients in relation to liver function

Ciclosporin, an immunosuppressant, is metabolized by the liver cytochrome P450 system. Changes in the pattern of its metabolites in blood and urine in patients with disturbed liver function have been studied. Forty seven kidney graft patients receiving 2.9 mg/kg/d ciclosporin b.i.d., and no addition...

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Veröffentlicht in:	European journal of clinical pharmacology 1991-01, Vol.40 (6), p.565-569
Hauptverfasser:	BLECK, J. S, SCHLITT, H. J, CHRISTIANS, U, SCHOTTMANN, R, THIESEMANN, C, STROHMEYER, S, KOHLHAW, K, WONIGEIT, K, PICHLMAYR, R, SEWING, K.-F
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Alkaline Phosphatase - blood Aspartate Aminotransferases - blood Bilirubin - blood Biological and medical sciences Cholestasis - metabolism Cholinesterases - blood Creatinine - urine Cyclosporins - blood Cyclosporins - metabolism Cyclosporins - urine Female gamma-Glutamyltransferase - blood Glutamate Dehydrogenase - blood Humans Immunomodulators Kidney Transplantation Liver - chemistry Liver - metabolism Liver Diseases - metabolism Male Medical sciences Pharmacology. Drug treatments
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