Pharmacokinetics of isradipine in patients with chronic liver disease

The pharmacokinetics of the dihydropyridine calcium antagonist isradipine has been examined in 8 healthy volunteers, 7 patients with non-cirrhotic chronic liver disease (CLD), and 8 patients with biopsy-proven cirrhosis (CIR). Isradipine was simultaneously given orally (12C 5 mg) and i.v. (13C 1 mg)...

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Veröffentlicht in:	European journal of clinical pharmacology 1990-01, Vol.38 (6), p.599-603
Hauptverfasser:	COTTING, J, REICHEN, J, KUTZ, K, LAPLANCHE, R, NUÊESCH, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aminopyrine - metabolism Antihypertensive agents Bile Acids and Salts - metabolism Biological and medical sciences Biotransformation Cardiovascular system Chronic Disease Hepatitis - metabolism Humans Indocyanine Green Injections, Intravenous Isradipine Liver Diseases - metabolism Liver Function Tests Male Medical sciences Middle Aged Models, Biological Pharmacology. Drug treatments Pyridines - administration & dosage Pyridines - adverse effects Pyridines - pharmacokinetics
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