An autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin
The intrarenal localisation of platinum following the intravenous administration of platinum-195m-labelled cisplatin, iproplatin and paraplatin was studied using autoradiography. Following injection of cisplatin, platinum was distributed throughout the kidney even up to 14 days after treatment. In t...
Gespeichert in:
| Veröffentlicht in: | Cancer chemotherapy and pharmacology 1988-01, Vol.22 (3), p.241-245 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 245 |
|---|---|
| container_issue | 3 |
| container_start_page | 241 |
| container_title | Cancer chemotherapy and pharmacology |
| container_volume | 22 |
| creator | EWEN, C PERERA, A HENDRY, J. H MCAULIFFE, C. A SHARMA, H FOX, B. W |
| description | The intrarenal localisation of platinum following the intravenous administration of platinum-195m-labelled cisplatin, iproplatin and paraplatin was studied using autoradiography. Following injection of cisplatin, platinum was distributed throughout the kidney even up to 14 days after treatment. In the case of iproplatin and paraplatin rapid platinum clearance was noted from the glomeruli, blood vessels and renal medulla within 2 h of administration. Relative cortical and medullary platinum radionuclide concentrations for all three agents were determined by Chalkley grid analysis. This showed greater relative concentrations of platinum in the cortex at increasing times following iproplatin and paraplatin compared with cisplatin. It is suggested that the lower renal toxicity of iproplatin and paraplatin than of cisplatin may be due to reduced platinum retention within the pars recta. |
| doi_str_mv | 10.1007/BF00273418 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF00273418</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3044632</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-e7c9328cc36f89736fa20942efc259b3a95a624d7771924cdb7a3a6e688244fa3</originalsourceid><addsrcrecordid>eNpFkD1PwzAQhi0EKqWwsCN5YEIE_HGN4xEqCkiVWGCOro5NjVInstOh_x7TVmW5D73Pne5eQq45e-CMqcfnOWNCSeDVCRlzkKJgFchTMmYSoJgqBufkIqUfxhhwKUdkJBlAKcWYhKdAcTN0ERvffUfsV97QNGyaLe0cHVaW-jBEjDZgS9vOYOsTDr7LU6Gh0Q427LoMG5_6Nmvhnvo-dvt6h_WYF-_aS3LmsE326pAn5Gv-8jl7KxYfr--zp0VhJOdDYZXRUlTGyNJVWuWIgmkQ1hkx1UuJeoqlgEYpxbUA0ywVSixtWVUCwKGckLv9XhO7lKJ1dR_9GuO25qz-86z-9yzDN3u43yzXtjmiB5OyfnvQMWUDXMSQfz1ipdb5DJC_Hxp0rw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>An autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>EWEN, C ; PERERA, A ; HENDRY, J. H ; MCAULIFFE, C. A ; SHARMA, H ; FOX, B. W</creator><creatorcontrib>EWEN, C ; PERERA, A ; HENDRY, J. H ; MCAULIFFE, C. A ; SHARMA, H ; FOX, B. W</creatorcontrib><description>The intrarenal localisation of platinum following the intravenous administration of platinum-195m-labelled cisplatin, iproplatin and paraplatin was studied using autoradiography. Following injection of cisplatin, platinum was distributed throughout the kidney even up to 14 days after treatment. In the case of iproplatin and paraplatin rapid platinum clearance was noted from the glomeruli, blood vessels and renal medulla within 2 h of administration. Relative cortical and medullary platinum radionuclide concentrations for all three agents were determined by Chalkley grid analysis. This showed greater relative concentrations of platinum in the cortex at increasing times following iproplatin and paraplatin compared with cisplatin. It is suggested that the lower renal toxicity of iproplatin and paraplatin than of cisplatin may be due to reduced platinum retention within the pars recta.</description><identifier>ISSN: 0344-5704</identifier><identifier>EISSN: 1432-0843</identifier><identifier>DOI: 10.1007/BF00273418</identifier><identifier>PMID: 3044632</identifier><identifier>CODEN: CCPHDZ</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Antineoplastic agents ; Antineoplastic Agents - pharmacokinetics ; Autoradiography ; Biological and medical sciences ; Carboplatin ; Cisplatin - pharmacokinetics ; General aspects ; Isotope Labeling ; Kidney - metabolism ; Male ; Medical sciences ; Mice ; Organoplatinum Compounds - pharmacokinetics ; Pharmacology. Drug treatments ; Platinum ; Quality Control ; Radioisotopes</subject><ispartof>Cancer chemotherapy and pharmacology, 1988-01, Vol.22 (3), p.241-245</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-e7c9328cc36f89736fa20942efc259b3a95a624d7771924cdb7a3a6e688244fa3</citedby><cites>FETCH-LOGICAL-c311t-e7c9328cc36f89736fa20942efc259b3a95a624d7771924cdb7a3a6e688244fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6997714$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3044632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EWEN, C</creatorcontrib><creatorcontrib>PERERA, A</creatorcontrib><creatorcontrib>HENDRY, J. H</creatorcontrib><creatorcontrib>MCAULIFFE, C. A</creatorcontrib><creatorcontrib>SHARMA, H</creatorcontrib><creatorcontrib>FOX, B. W</creatorcontrib><title>An autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin</title><title>Cancer chemotherapy and pharmacology</title><addtitle>Cancer Chemother Pharmacol</addtitle><description>The intrarenal localisation of platinum following the intravenous administration of platinum-195m-labelled cisplatin, iproplatin and paraplatin was studied using autoradiography. Following injection of cisplatin, platinum was distributed throughout the kidney even up to 14 days after treatment. In the case of iproplatin and paraplatin rapid platinum clearance was noted from the glomeruli, blood vessels and renal medulla within 2 h of administration. Relative cortical and medullary platinum radionuclide concentrations for all three agents were determined by Chalkley grid analysis. This showed greater relative concentrations of platinum in the cortex at increasing times following iproplatin and paraplatin compared with cisplatin. It is suggested that the lower renal toxicity of iproplatin and paraplatin than of cisplatin may be due to reduced platinum retention within the pars recta.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Carboplatin</subject><subject>Cisplatin - pharmacokinetics</subject><subject>General aspects</subject><subject>Isotope Labeling</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Organoplatinum Compounds - pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Platinum</subject><subject>Quality Control</subject><subject>Radioisotopes</subject><issn>0344-5704</issn><issn>1432-0843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAQhi0EKqWwsCN5YEIE_HGN4xEqCkiVWGCOro5NjVInstOh_x7TVmW5D73Pne5eQq45e-CMqcfnOWNCSeDVCRlzkKJgFchTMmYSoJgqBufkIqUfxhhwKUdkJBlAKcWYhKdAcTN0ERvffUfsV97QNGyaLe0cHVaW-jBEjDZgS9vOYOsTDr7LU6Gh0Q427LoMG5_6Nmvhnvo-dvt6h_WYF-_aS3LmsE326pAn5Gv-8jl7KxYfr--zp0VhJOdDYZXRUlTGyNJVWuWIgmkQ1hkx1UuJeoqlgEYpxbUA0ywVSixtWVUCwKGckLv9XhO7lKJ1dR_9GuO25qz-86z-9yzDN3u43yzXtjmiB5OyfnvQMWUDXMSQfz1ipdb5DJC_Hxp0rw</recordid><startdate>19880101</startdate><enddate>19880101</enddate><creator>EWEN, C</creator><creator>PERERA, A</creator><creator>HENDRY, J. H</creator><creator>MCAULIFFE, C. A</creator><creator>SHARMA, H</creator><creator>FOX, B. W</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19880101</creationdate><title>An autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin</title><author>EWEN, C ; PERERA, A ; HENDRY, J. H ; MCAULIFFE, C. A ; SHARMA, H ; FOX, B. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-e7c9328cc36f89736fa20942efc259b3a95a624d7771924cdb7a3a6e688244fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Carboplatin</topic><topic>Cisplatin - pharmacokinetics</topic><topic>General aspects</topic><topic>Isotope Labeling</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Organoplatinum Compounds - pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Platinum</topic><topic>Quality Control</topic><topic>Radioisotopes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EWEN, C</creatorcontrib><creatorcontrib>PERERA, A</creatorcontrib><creatorcontrib>HENDRY, J. H</creatorcontrib><creatorcontrib>MCAULIFFE, C. A</creatorcontrib><creatorcontrib>SHARMA, H</creatorcontrib><creatorcontrib>FOX, B. W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Cancer chemotherapy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EWEN, C</au><au>PERERA, A</au><au>HENDRY, J. H</au><au>MCAULIFFE, C. A</au><au>SHARMA, H</au><au>FOX, B. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin</atitle><jtitle>Cancer chemotherapy and pharmacology</jtitle><addtitle>Cancer Chemother Pharmacol</addtitle><date>1988-01-01</date><risdate>1988</risdate><volume>22</volume><issue>3</issue><spage>241</spage><epage>245</epage><pages>241-245</pages><issn>0344-5704</issn><eissn>1432-0843</eissn><coden>CCPHDZ</coden><abstract>The intrarenal localisation of platinum following the intravenous administration of platinum-195m-labelled cisplatin, iproplatin and paraplatin was studied using autoradiography. Following injection of cisplatin, platinum was distributed throughout the kidney even up to 14 days after treatment. In the case of iproplatin and paraplatin rapid platinum clearance was noted from the glomeruli, blood vessels and renal medulla within 2 h of administration. Relative cortical and medullary platinum radionuclide concentrations for all three agents were determined by Chalkley grid analysis. This showed greater relative concentrations of platinum in the cortex at increasing times following iproplatin and paraplatin compared with cisplatin. It is suggested that the lower renal toxicity of iproplatin and paraplatin than of cisplatin may be due to reduced platinum retention within the pars recta.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>3044632</pmid><doi>10.1007/BF00273418</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0344-5704 |
| ispartof | Cancer chemotherapy and pharmacology, 1988-01, Vol.22 (3), p.241-245 |
| issn | 0344-5704 1432-0843 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00273418 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Antineoplastic agents Antineoplastic Agents - pharmacokinetics Autoradiography Biological and medical sciences Carboplatin Cisplatin - pharmacokinetics General aspects Isotope Labeling Kidney - metabolism Male Medical sciences Mice Organoplatinum Compounds - pharmacokinetics Pharmacology. Drug treatments Platinum Quality Control Radioisotopes |
| title | An autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T08%3A10%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20autoradiographic%20study%20of%20the%20intrarenal%20localisation%20and%20retention%20of%20cisplatin,%20iproplatin%20and%20paraplatin&rft.jtitle=Cancer%20chemotherapy%20and%20pharmacology&rft.au=EWEN,%20C&rft.date=1988-01-01&rft.volume=22&rft.issue=3&rft.spage=241&rft.epage=245&rft.pages=241-245&rft.issn=0344-5704&rft.eissn=1432-0843&rft.coden=CCPHDZ&rft_id=info:doi/10.1007/BF00273418&rft_dat=%3Cpubmed_cross%3E3044632%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/3044632&rfr_iscdi=true |