The effects of dimercaptosuccinic acid and other chelating agents on the retention of platinum in the rat kidney after treatment with cisplatin

The ability of three chelating agents, dimercaptopropanesulphonate (DMPS), dimercaptosuccinic acid (DMSA), and diethylenetriaminepentaacetic acid (DPTA), to reduce the retention of platinum in the kidneys was tested in male Sprague-Dawley rats treated 24 h previously with Cisplatin. DMPS and DMSA, w...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1982, Vol.9 (2), p.120-121
Hauptverfasser:	Planas-Bohne, F, Shand, E, Taylor, D M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chelating Agents - pharmacology Cisplatin - metabolism Drug Interactions Kidney - metabolism Male Platinum - metabolism Rats Rats, Inbred Strains Succimer - pharmacology Sulfhydryl Compounds - pharmacology
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