The effects of dimercaptosuccinic acid and other chelating agents on the retention of platinum in the rat kidney after treatment with cisplatin

The ability of three chelating agents, dimercaptopropanesulphonate (DMPS), dimercaptosuccinic acid (DMSA), and diethylenetriaminepentaacetic acid (DPTA), to reduce the retention of platinum in the kidneys was tested in male Sprague-Dawley rats treated 24 h previously with Cisplatin. DMPS and DMSA, w...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1982, Vol.9 (2), p.120-121
Hauptverfasser:	Planas-Bohne, F, Shand, E, Taylor, D M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chelating Agents - pharmacology Cisplatin - metabolism Drug Interactions Kidney - metabolism Male Platinum - metabolism Rats Rats, Inbred Strains Succimer - pharmacology Sulfhydryl Compounds - pharmacology
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container_title	Cancer chemotherapy and pharmacology
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creator	Planas-Bohne, F Shand, E Taylor, D M
description	The ability of three chelating agents, dimercaptopropanesulphonate (DMPS), dimercaptosuccinic acid (DMSA), and diethylenetriaminepentaacetic acid (DPTA), to reduce the retention of platinum in the kidneys was tested in male Sprague-Dawley rats treated 24 h previously with Cisplatin. DMPS and DMSA, when given as four daily doses of 1 mMol/kg, increased the urinary excretion from 10.1% +/- 1.2% to 13.6% +/- 1.3% and 13.5% +/- 2.6%, respectively, but only DMSA caused a small but significant reduction in the kidney platinum content. DTPA was totally ineffective. It is concluded that none of these agents is likely to be useful for the reduction of Cisplatin-induced renal toxicity in the clinical situation.
doi_str_mv	10.1007/BF00265392
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DMPS and DMSA, when given as four daily doses of 1 mMol/kg, increased the urinary excretion from 10.1% +/- 1.2% to 13.6% +/- 1.3% and 13.5% +/- 2.6%, respectively, but only DMSA caused a small but significant reduction in the kidney platinum content. DTPA was totally ineffective. It is concluded that none of these agents is likely to be useful for the reduction of Cisplatin-induced renal toxicity in the clinical situation.</description><identifier>ISSN: 0344-5704</identifier><identifier>EISSN: 1432-0843</identifier><identifier>DOI: 10.1007/BF00265392</identifier><identifier>PMID: 6293731</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; Chelating Agents - pharmacology ; Cisplatin - metabolism ; Drug Interactions ; Kidney - metabolism ; Male ; Platinum - metabolism ; Rats ; Rats, Inbred Strains ; Succimer - pharmacology ; Sulfhydryl Compounds - pharmacology</subject><ispartof>Cancer chemotherapy and pharmacology, 1982, Vol.9 (2), p.120-121</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-c2ee6e44502bdb9b356c080ba520740923ae54418d5f75ac0dc3c4274df95ebb3</citedby><cites>FETCH-LOGICAL-c282t-c2ee6e44502bdb9b356c080ba520740923ae54418d5f75ac0dc3c4274df95ebb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6293731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Planas-Bohne, F</creatorcontrib><creatorcontrib>Shand, E</creatorcontrib><creatorcontrib>Taylor, D M</creatorcontrib><title>The effects of dimercaptosuccinic acid and other chelating agents on the retention of platinum in the rat kidney after treatment with cisplatin</title><title>Cancer chemotherapy and pharmacology</title><addtitle>Cancer Chemother Pharmacol</addtitle><description>The ability of three chelating agents, dimercaptopropanesulphonate (DMPS), dimercaptosuccinic acid (DMSA), and diethylenetriaminepentaacetic acid (DPTA), to reduce the retention of platinum in the kidneys was tested in male Sprague-Dawley rats treated 24 h previously with Cisplatin. DMPS and DMSA, when given as four daily doses of 1 mMol/kg, increased the urinary excretion from 10.1% +/- 1.2% to 13.6% +/- 1.3% and 13.5% +/- 2.6%, respectively, but only DMSA caused a small but significant reduction in the kidney platinum content. DTPA was totally ineffective. It is concluded that none of these agents is likely to be useful for the reduction of Cisplatin-induced renal toxicity in the clinical situation.</description><subject>Animals</subject><subject>Chelating Agents - pharmacology</subject><subject>Cisplatin - metabolism</subject><subject>Drug Interactions</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Platinum - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Succimer - pharmacology</subject><subject>Sulfhydryl Compounds - pharmacology</subject><issn>0344-5704</issn><issn>1432-0843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLAzEUhYMotVY37oWshdE7ecxjqcWqUHBT10MmuelEOw-SFOmv8C87tUU393I43zmLQ8h1CncpQH7_uABgmeQlOyHTVHCWQCH4KZkCFyKROYhzchHCBwCIlPMJmWSs5DlPp-R71SBFa1HHQHtLjWvRazXEPmy1dp3TVGlnqOoM7WODnuoGNyq6bk3VGrt9qqOjQT3GUbpRjTXDL7JtqTuaKtJPZzrcUWXj2BI9qtiOAfrlYkO1C4fIJTmzahPw6vhn5H3xtJq_JMu359f5wzLRrGBxvIgZCiGB1aYuay4zDQXUSjLIBZSMK5RCpIWRNpdKg9FcC5YLY0uJdc1n5PbQq30fgkdbDd61yu-qFKr9qNX_qCN8c4CHbd2i-UOPK_IfUgJ0Wg</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Planas-Bohne, F</creator><creator>Shand, E</creator><creator>Taylor, D M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1982</creationdate><title>The effects of dimercaptosuccinic acid and other chelating agents on the retention of platinum in the rat kidney after treatment with cisplatin</title><author>Planas-Bohne, F ; Shand, E ; Taylor, D M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-c2ee6e44502bdb9b356c080ba520740923ae54418d5f75ac0dc3c4274df95ebb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Chelating Agents - pharmacology</topic><topic>Cisplatin - metabolism</topic><topic>Drug Interactions</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Platinum - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Succimer - pharmacology</topic><topic>Sulfhydryl Compounds - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Planas-Bohne, F</creatorcontrib><creatorcontrib>Shand, E</creatorcontrib><creatorcontrib>Taylor, D M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Cancer chemotherapy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Planas-Bohne, F</au><au>Shand, E</au><au>Taylor, D M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of dimercaptosuccinic acid and other chelating agents on the retention of platinum in the rat kidney after treatment with cisplatin</atitle><jtitle>Cancer chemotherapy and pharmacology</jtitle><addtitle>Cancer Chemother Pharmacol</addtitle><date>1982</date><risdate>1982</risdate><volume>9</volume><issue>2</issue><spage>120</spage><epage>121</epage><pages>120-121</pages><issn>0344-5704</issn><eissn>1432-0843</eissn><abstract>The ability of three chelating agents, dimercaptopropanesulphonate (DMPS), dimercaptosuccinic acid (DMSA), and diethylenetriaminepentaacetic acid (DPTA), to reduce the retention of platinum in the kidneys was tested in male Sprague-Dawley rats treated 24 h previously with Cisplatin. DMPS and DMSA, when given as four daily doses of 1 mMol/kg, increased the urinary excretion from 10.1% +/- 1.2% to 13.6% +/- 1.3% and 13.5% +/- 2.6%, respectively, but only DMSA caused a small but significant reduction in the kidney platinum content. DTPA was totally ineffective. It is concluded that none of these agents is likely to be useful for the reduction of Cisplatin-induced renal toxicity in the clinical situation.</abstract><cop>Germany</cop><pmid>6293731</pmid><doi>10.1007/BF00265392</doi><tpages>2</tpages></addata></record>
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subjects	Animals Chelating Agents - pharmacology Cisplatin - metabolism Drug Interactions Kidney - metabolism Male Platinum - metabolism Rats Rats, Inbred Strains Succimer - pharmacology Sulfhydryl Compounds - pharmacology
title	The effects of dimercaptosuccinic acid and other chelating agents on the retention of platinum in the rat kidney after treatment with cisplatin
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