Inactivation of cis-diamminedichloroplatinum (II) in blood and protection of its toxicity by sodium thiosulfate in rabbits
The mode of inactivation of cis-diamminedichloroplatinum(II) (DDP) in the bloodstream and protection from its toxicity by sodium thiosulfate (STS) were investigated in rabbits. Plasma ultrafiltrate in rabbits given 5 mg/kg DDP IV and various excess molar ratios of STS IV were assayed for the active...
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| Veröffentlicht in: | Cancer chemotherapy and pharmacology 1985-10, Vol.15 (3), p.228-232 |
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| container_title | Cancer chemotherapy and pharmacology |
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| creator | IWAMOTO, Y KAWANO, T ISHIZAWA, M AOKI, K KUROIWA, T BABA, T |
| description | The mode of inactivation of cis-diamminedichloroplatinum(II) (DDP) in the bloodstream and protection from its toxicity by sodium thiosulfate (STS) were investigated in rabbits. Plasma ultrafiltrate in rabbits given 5 mg/kg DDP IV and various excess molar ratios of STS IV were assayed for the active platinum levels with a new microbiological assay system using an E. coli strain. The active platinum species in the plasma were inactivated completely by co-administration of a 400-fold excess of STS IV. The rabbits were almost completely protected against both BUN increase and body weight loss normally caused by DDP when 400-fold doses of STS were given. Diuretic effects were also observed. Our data provide evidence for the basis of optimum use of STS to protect against DDP toxicity. |
| doi_str_mv | 10.1007/bf00263891 |
| format | Article |
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Plasma ultrafiltrate in rabbits given 5 mg/kg DDP IV and various excess molar ratios of STS IV were assayed for the active platinum levels with a new microbiological assay system using an E. coli strain. The active platinum species in the plasma were inactivated completely by co-administration of a 400-fold excess of STS IV. The rabbits were almost completely protected against both BUN increase and body weight loss normally caused by DDP when 400-fold doses of STS were given. Diuretic effects were also observed. Our data provide evidence for the basis of optimum use of STS to protect against DDP toxicity.</description><identifier>ISSN: 0344-5704</identifier><identifier>EISSN: 1432-0843</identifier><identifier>DOI: 10.1007/bf00263891</identifier><identifier>PMID: 3902266</identifier><identifier>CODEN: CCPHDZ</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Antineoplastic agents ; Biological and medical sciences ; Cisplatin - blood ; Cisplatin - pharmacology ; Cisplatin - toxicity ; Drug Interactions ; Escherichia coli - drug effects ; Female ; General aspects ; Kinetics ; Medical sciences ; Pharmacology. 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Plasma ultrafiltrate in rabbits given 5 mg/kg DDP IV and various excess molar ratios of STS IV were assayed for the active platinum levels with a new microbiological assay system using an E. coli strain. The active platinum species in the plasma were inactivated completely by co-administration of a 400-fold excess of STS IV. The rabbits were almost completely protected against both BUN increase and body weight loss normally caused by DDP when 400-fold doses of STS were given. Diuretic effects were also observed. Our data provide evidence for the basis of optimum use of STS to protect against DDP toxicity.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cisplatin - blood</subject><subject>Cisplatin - pharmacology</subject><subject>Cisplatin - toxicity</subject><subject>Drug Interactions</subject><subject>Escherichia coli - drug effects</subject><subject>Female</subject><subject>General aspects</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Spectrophotometry, Atomic</subject><subject>Thiosulfates - pharmacology</subject><subject>Ultrafiltration</subject><issn>0344-5704</issn><issn>1432-0843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhoMo67p68S7k4EGFatqkTXvUxdXCghc9l8kXG2mb0mTF9debZT9Ow_A-78A8CF2n5DElhD8JQ0hW0LJKT9A0ZTRLSMnoKZoSyliSc8LO0YX334QQllI6QRNakSwriin6q3uQwf5AsK7HzmBpfaIsdJ3ttbJy1brRDW2M-3WH7-r6Htsei9Y5haFXeBhd0PJQtsHj4H6ttGGDxQZ7p2yshZV1ft0aCHrbHkGISF6iMwOt11f7OUNfi9fP-Xuy_Hir58_LRFLOQ8IJ0SovmVa64vFJUWSlKisheMYEM4JKzSAHYFkFueYFGG0yJeOSVpyBoDP0sLsrR-f9qE0zjLaDcdOkpNn6a14WB38RvtnBw1p0Wh3RvbCY3-5z8BJaM0IfjR2xMiclZzn9BwncegM</recordid><startdate>198510</startdate><enddate>198510</enddate><creator>IWAMOTO, Y</creator><creator>KAWANO, T</creator><creator>ISHIZAWA, M</creator><creator>AOKI, K</creator><creator>KUROIWA, T</creator><creator>BABA, T</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198510</creationdate><title>Inactivation of cis-diamminedichloroplatinum (II) in blood and protection of its toxicity by sodium thiosulfate in rabbits</title><author>IWAMOTO, Y ; KAWANO, T ; ISHIZAWA, M ; AOKI, K ; KUROIWA, T ; BABA, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-700ed584ede97638b628d89bb724b4fb3ce4a5aa429a5e76afef2dc9a51974ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Cisplatin - blood</topic><topic>Cisplatin - pharmacology</topic><topic>Cisplatin - toxicity</topic><topic>Drug Interactions</topic><topic>Escherichia coli - drug effects</topic><topic>Female</topic><topic>General aspects</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabbits</topic><topic>Spectrophotometry, Atomic</topic><topic>Thiosulfates - pharmacology</topic><topic>Ultrafiltration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IWAMOTO, Y</creatorcontrib><creatorcontrib>KAWANO, T</creatorcontrib><creatorcontrib>ISHIZAWA, M</creatorcontrib><creatorcontrib>AOKI, K</creatorcontrib><creatorcontrib>KUROIWA, T</creatorcontrib><creatorcontrib>BABA, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Cancer chemotherapy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IWAMOTO, Y</au><au>KAWANO, T</au><au>ISHIZAWA, M</au><au>AOKI, K</au><au>KUROIWA, T</au><au>BABA, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inactivation of cis-diamminedichloroplatinum (II) in blood and protection of its toxicity by sodium thiosulfate in rabbits</atitle><jtitle>Cancer chemotherapy and pharmacology</jtitle><addtitle>Cancer Chemother Pharmacol</addtitle><date>1985-10</date><risdate>1985</risdate><volume>15</volume><issue>3</issue><spage>228</spage><epage>232</epage><pages>228-232</pages><issn>0344-5704</issn><eissn>1432-0843</eissn><coden>CCPHDZ</coden><abstract>The mode of inactivation of cis-diamminedichloroplatinum(II) (DDP) in the bloodstream and protection from its toxicity by sodium thiosulfate (STS) were investigated in rabbits. Plasma ultrafiltrate in rabbits given 5 mg/kg DDP IV and various excess molar ratios of STS IV were assayed for the active platinum levels with a new microbiological assay system using an E. coli strain. The active platinum species in the plasma were inactivated completely by co-administration of a 400-fold excess of STS IV. The rabbits were almost completely protected against both BUN increase and body weight loss normally caused by DDP when 400-fold doses of STS were given. Diuretic effects were also observed. Our data provide evidence for the basis of optimum use of STS to protect against DDP toxicity.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>3902266</pmid><doi>10.1007/bf00263891</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0344-5704 |
| ispartof | Cancer chemotherapy and pharmacology, 1985-10, Vol.15 (3), p.228-232 |
| issn | 0344-5704 1432-0843 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00263891 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Antineoplastic agents Biological and medical sciences Cisplatin - blood Cisplatin - pharmacology Cisplatin - toxicity Drug Interactions Escherichia coli - drug effects Female General aspects Kinetics Medical sciences Pharmacology. Drug treatments Rabbits Spectrophotometry, Atomic Thiosulfates - pharmacology Ultrafiltration |
| title | Inactivation of cis-diamminedichloroplatinum (II) in blood and protection of its toxicity by sodium thiosulfate in rabbits |
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