Platinum drugs: combined anti-lymphoproliferative and nephrotoxicity assay in rats

A 4-day drug schedule was used to explore the efficacy and simultaneous toxicity of cisplatin and 30 other platinum (II) amines given IP to PVG x Lew F1 hybrid rats at cumulative doses of 10-300 mumol/kg. Toxic effects monitored were stomach enlargement, kidney hypertrophy with tubular necrosis and...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1980-01, Vol.4 (4), p.249
Hauptverfasser:	Aggarwal, S K, Broomhead, J A, Fairlie, D P, Whitehouse, M W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Cell Division - drug effects Hydrolysis Kidney Diseases - chemically induced Kidney Diseases - pathology Lymphocytes - drug effects Platinum - pharmacology Platinum - toxicity Rats Time Factors
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