Combination chemotherapy (high-dose methotrexate with citrovorum factor rexue, mechlorethamine, and procarbazine) in non-small cell lung cancer

Twenty-five patients with non-small cell lung cancer (NSCLC) were treated with high-dose methotrexate with citrovorum factor resuce (HDMTX-CFR), mechlorethamine (HN2) and procarbazine (PCZ). Nineteen patients are evaluable for response. One patient had partial remission which lasted for 11 weeks. Ni...

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Veröffentlicht in:Cancer chemotherapy and pharmacology 1983, Vol.11 (2), p.106-107
Hauptverfasser: BHASIN, R. R, NOGEIRIE, C. P
Format: Artikel
Sprache:eng
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Zusammenfassung:Twenty-five patients with non-small cell lung cancer (NSCLC) were treated with high-dose methotrexate with citrovorum factor resuce (HDMTX-CFR), mechlorethamine (HN2) and procarbazine (PCZ). Nineteen patients are evaluable for response. One patient had partial remission which lasted for 11 weeks. Nine patients had stable disease lasting for 6-22 weeks. HDMTX-CFR was well tolerated by these patients but this combination regimen produced very low tumor response rate (5.2%). Addition of HN2 and PCZ, chemotherapeutic agents active against NSCLC, failed to improve the tumor response rate but added to gastrointestinal and hematologic toxicity.
ISSN:0344-5704
1432-0843
DOI:10.1007/BF00254256