Clinical results with 131I-toluidine blue and triple radionuclide subtraction for preoperative localization of enlarged parathyroid glands
Clinical results from the application of a triple radionuclide subtraction study for preoperative localization of enlarged parathyroid glands are presented in this paper. A scintillation camera image was recorded after i.v. injection of 131I-toluidine blue. The contributions to this image from activ...
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| Veröffentlicht in: | European Journal of Nuclear Medicine 1978, Vol.3 (1), p.5-9 |
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| creator | Skretting, A Aas, M Normann, E Sødal, G Lindegaard, M W |
| description | Clinical results from the application of a triple radionuclide subtraction study for preoperative localization of enlarged parathyroid glands are presented in this paper. A scintillation camera image was recorded after i.v. injection of 131I-toluidine blue. The contributions to this image from activity in the thyroid gland and in blood were determined after recording of additional images (obtained after injection of 99mTcO4- and 113mIn, respectively) using an iterative computer algorithm that also provides an estimate for a uniform background. Subtraction of these contributions gives an image that may be interpreted as an image of the selective accumulation of 131I-toluidine blue in the parathyroids. One or more enlarged glands were correctly localized in 17 of 21 cases, but in four cases there were only false positives. In ten cases the correctly localized glands weighed 900 mg or less. |
| doi_str_mv | 10.1007/BF00253470 |
| format | Article |
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A scintillation camera image was recorded after i.v. injection of 131I-toluidine blue. The contributions to this image from activity in the thyroid gland and in blood were determined after recording of additional images (obtained after injection of 99mTcO4- and 113mIn, respectively) using an iterative computer algorithm that also provides an estimate for a uniform background. Subtraction of these contributions gives an image that may be interpreted as an image of the selective accumulation of 131I-toluidine blue in the parathyroids. One or more enlarged glands were correctly localized in 17 of 21 cases, but in four cases there were only false positives. In ten cases the correctly localized glands weighed 900 mg or less.</description><identifier>ISSN: 0340-6997</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/BF00253470</identifier><identifier>PMID: 753623</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Aged ; Computers ; False Positive Reactions ; Female ; Humans ; Indium ; Iodine Radioisotopes ; Male ; Middle Aged ; Parathyroid Diseases - diagnostic imaging ; Radioisotopes ; Radionuclide Imaging - methods ; Technetium ; Tolonium Chloride</subject><ispartof>European Journal of Nuclear Medicine, 1978, Vol.3 (1), p.5-9</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1283-bba2a7438096680b1c11577991c35292307d38a67208276c8688130fc6a6b4d23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4012,27910,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/753623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skretting, A</creatorcontrib><creatorcontrib>Aas, M</creatorcontrib><creatorcontrib>Normann, E</creatorcontrib><creatorcontrib>Sødal, G</creatorcontrib><creatorcontrib>Lindegaard, M W</creatorcontrib><title>Clinical results with 131I-toluidine blue and triple radionuclide subtraction for preoperative localization of enlarged parathyroid glands</title><title>European Journal of Nuclear Medicine</title><addtitle>Eur J Nucl Med</addtitle><description>Clinical results from the application of a triple radionuclide subtraction study for preoperative localization of enlarged parathyroid glands are presented in this paper. A scintillation camera image was recorded after i.v. injection of 131I-toluidine blue. The contributions to this image from activity in the thyroid gland and in blood were determined after recording of additional images (obtained after injection of 99mTcO4- and 113mIn, respectively) using an iterative computer algorithm that also provides an estimate for a uniform background. Subtraction of these contributions gives an image that may be interpreted as an image of the selective accumulation of 131I-toluidine blue in the parathyroids. One or more enlarged glands were correctly localized in 17 of 21 cases, but in four cases there were only false positives. In ten cases the correctly localized glands weighed 900 mg or less.</description><subject>Adult</subject><subject>Aged</subject><subject>Computers</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>Humans</subject><subject>Indium</subject><subject>Iodine Radioisotopes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parathyroid Diseases - diagnostic imaging</subject><subject>Radioisotopes</subject><subject>Radionuclide Imaging - methods</subject><subject>Technetium</subject><subject>Tolonium Chloride</subject><issn>0340-6997</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAQQC3EVykszAyeGJACZzuxnREqPipVYoE5cmynNXLjYCcg-An8agKtYDrp7unp9BA6JXBJAMTVzR0ALVguYAdNCCdlJkCWu2gCLIeMl6U4REcpvQBAnrPiAO2LgnHKJuhr5l3rtPI42jT4PuF3168wYWSe9cEPzrjW4toPFqvW4D66zlsclXGhHbR3xuI01H1Uuh83uAkRd9GGzkbVuzeLfRjd7lP9XkODbetVXFqDOzUSq48YnMFLP7rTMdprlE_2ZDun6Pnu9mn2kC0e7-ez60WmCZUsq2tFlciZhJJzCTXRhBRClCXRrKAlZSAMk4oLCpIKriWXkjBoNFe8zg1lU3S-8XYxvA429dXaJW39-IQNQ6pEngPjhIzgxQbUMaQUbVN10a1V_KgIVD_dq__uI3y2tQ712po_dBOafQMvsX4C</recordid><startdate>1978</startdate><enddate>1978</enddate><creator>Skretting, A</creator><creator>Aas, M</creator><creator>Normann, E</creator><creator>Sødal, G</creator><creator>Lindegaard, M W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1978</creationdate><title>Clinical results with 131I-toluidine blue and triple radionuclide subtraction for preoperative localization of enlarged parathyroid glands</title><author>Skretting, A ; Aas, M ; Normann, E ; Sødal, G ; Lindegaard, M W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1283-bba2a7438096680b1c11577991c35292307d38a67208276c8688130fc6a6b4d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Computers</topic><topic>False Positive Reactions</topic><topic>Female</topic><topic>Humans</topic><topic>Indium</topic><topic>Iodine Radioisotopes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Parathyroid Diseases - diagnostic imaging</topic><topic>Radioisotopes</topic><topic>Radionuclide Imaging - methods</topic><topic>Technetium</topic><topic>Tolonium Chloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skretting, A</creatorcontrib><creatorcontrib>Aas, M</creatorcontrib><creatorcontrib>Normann, E</creatorcontrib><creatorcontrib>Sødal, G</creatorcontrib><creatorcontrib>Lindegaard, M W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European Journal of Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skretting, A</au><au>Aas, M</au><au>Normann, E</au><au>Sødal, G</au><au>Lindegaard, M W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical results with 131I-toluidine blue and triple radionuclide subtraction for preoperative localization of enlarged parathyroid glands</atitle><jtitle>European Journal of Nuclear Medicine</jtitle><addtitle>Eur J Nucl Med</addtitle><date>1978</date><risdate>1978</risdate><volume>3</volume><issue>1</issue><spage>5</spage><epage>9</epage><pages>5-9</pages><issn>0340-6997</issn><eissn>1619-7089</eissn><abstract>Clinical results from the application of a triple radionuclide subtraction study for preoperative localization of enlarged parathyroid glands are presented in this paper. A scintillation camera image was recorded after i.v. injection of 131I-toluidine blue. The contributions to this image from activity in the thyroid gland and in blood were determined after recording of additional images (obtained after injection of 99mTcO4- and 113mIn, respectively) using an iterative computer algorithm that also provides an estimate for a uniform background. Subtraction of these contributions gives an image that may be interpreted as an image of the selective accumulation of 131I-toluidine blue in the parathyroids. One or more enlarged glands were correctly localized in 17 of 21 cases, but in four cases there were only false positives. In ten cases the correctly localized glands weighed 900 mg or less.</abstract><cop>Germany</cop><pmid>753623</pmid><doi>10.1007/BF00253470</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-6997 |
| ispartof | European Journal of Nuclear Medicine, 1978, Vol.3 (1), p.5-9 |
| issn | 0340-6997 1619-7089 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00253470 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Computers False Positive Reactions Female Humans Indium Iodine Radioisotopes Male Middle Aged Parathyroid Diseases - diagnostic imaging Radioisotopes Radionuclide Imaging - methods Technetium Tolonium Chloride |
| title | Clinical results with 131I-toluidine blue and triple radionuclide subtraction for preoperative localization of enlarged parathyroid glands |
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