Role of radio-aerosol and perfusion lung imaging in early detection of chronic obstructive lung disease

The efficacy of radio-aerosol and perfusion lung imaging in the early detection of chronic obstructive lung disease was evaluated in 38 subjects. The subjects included 5 non-smokers, 21 smokers with minimal or no respiratory symptoms and 12 patients with chronic obstructive lung disease. Each subjec...

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Veröffentlicht in:European Journal of Nuclear Medicine 1983-01, Vol.8 (4), p.167-171
Hauptverfasser: Garg, A, Gopinath, P G, Pande, J N, Guleria, J S
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container_end_page 171
container_issue 4
container_start_page 167
container_title European Journal of Nuclear Medicine
container_volume 8
creator Garg, A
Gopinath, P G
Pande, J N
Guleria, J S
description The efficacy of radio-aerosol and perfusion lung imaging in the early detection of chronic obstructive lung disease was evaluated in 38 subjects. The subjects included 5 non-smokers, 21 smokers with minimal or no respiratory symptoms and 12 patients with chronic obstructive lung disease. Each subject consented to a respiratory questionnaire, detailed physical examination, chest X-ray examinations, detailed pulmonary function tests and 99mTc-radio aerosol-inhalation lung imaging. Perfusion lung imaging with 99mTc-labelled macroaggregated albumin was performed in 22 subjects. A significant correlation (P less than 0.001) was observed between the degree of abnormalities on radio-aerosol imaging and pulmonary function tests (PFTs) including forced expiratory volume in 1 s, maximum mid-expiratory flow rate and mean transit time analysis. Abnormal radio-aerosol patterns and deranged PFTs were observed in 21 subjects each. Of 21 subjects with abnormal radioaerosol pattern 8 had normal PFTs. Of 21 subjects with abnormal PFTs 8 had normal aerosol images. Aerosol lung images and PFTs were abnormal more frequently than perfusion lung images. The results suggest that radio-aerosol lung imaging is as sensitive an indicator as PFTs for early detection of chronic obstructive lung disease and can be usefully combined with PFTs for early detection of alteration in pulmonary physiology in smokers.
doi_str_mv 10.1007/BF00252889
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source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Adolescent
Adult
Aged
Humans
Lung Diseases, Obstructive - diagnostic imaging
Male
Middle Aged
Perfusion
Radionuclide Imaging
Respiratory Function Tests
Serum Albumin
Technetium
Technetium Tc 99m Aggregated Albumin
title Role of radio-aerosol and perfusion lung imaging in early detection of chronic obstructive lung disease
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