Agranulocytosis induced by antithyroid therapy : effects of treatment with granulocyte colony stimulating factor
A 26-year-old woman was admitted to hospital with high fever, severe tonsillitis, and gastroenteritis. Because of Graves' disease she had been treated with methimazole for 18 months. Leukopenia and agranulocytosis in combination with a typical bone marrow, exhibiting a complete arrest of myelop...
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| Veröffentlicht in: | The Clinical Investigator 1994-05, Vol.72 (5), p.390-392 |
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| creator | ADORF, D GRAJER, K. H KABOTH, W NERL, C |
| description | A 26-year-old woman was admitted to hospital with high fever, severe tonsillitis, and gastroenteritis. Because of Graves' disease she had been treated with methimazole for 18 months. Leukopenia and agranulocytosis in combination with a typical bone marrow, exhibiting a complete arrest of myelopoiesis at the stage of promyelocytes led to the diagnosis of an antithyroid therapy induced agranulocytosis. After 1 week of antibiotic treatment without changes in neutrophil counts, granulocyte colony stimulating factor treatment at a dose of 300 micrograms/day subcutaneously was started. Twenty-four hours after the first administration the neutrophil counts began to rise, to 4389/microliters, with a maximum after the third administration and stabilizing at normal levels within 10 days. Since agranulocytosis is considered to be a severe and fatal complication of methimazole therapy, treatment with granulocyte colony stimulating factor seems to be useful for this life-threatening condition. |
| doi_str_mv | 10.1007/BF00252834 |
| format | Article |
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Since agranulocytosis is considered to be a severe and fatal complication of methimazole therapy, treatment with granulocyte colony stimulating factor seems to be useful for this life-threatening condition.</description><identifier>ISSN: 0941-0198</identifier><identifier>EISSN: 1432-1440</identifier><identifier>DOI: 10.1007/BF00252834</identifier><identifier>PMID: 7522068</identifier><language>eng</language><publisher>Heidelberg: Springer-Verlag</publisher><subject>Adult ; Agranulocytosis - chemically induced ; Agranulocytosis - complications ; Agranulocytosis - pathology ; Agranulocytosis - therapy ; Biological and medical sciences ; Bone Marrow - pathology ; Drug toxicity and drugs side effects treatment ; Female ; Granulocyte Colony-Stimulating Factor - therapeutic use ; Graves Disease - complications ; Graves Disease - drug therapy ; Humans ; Immunologic Factors - therapeutic use ; Infection - etiology ; Leukocyte Count - drug effects ; Medical sciences ; Methimazole - adverse effects ; Pharmacology. 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H</creatorcontrib><creatorcontrib>KABOTH, W</creatorcontrib><creatorcontrib>NERL, C</creatorcontrib><title>Agranulocytosis induced by antithyroid therapy : effects of treatment with granulocyte colony stimulating factor</title><title>The Clinical Investigator</title><addtitle>Clin Investig</addtitle><description>A 26-year-old woman was admitted to hospital with high fever, severe tonsillitis, and gastroenteritis. Because of Graves' disease she had been treated with methimazole for 18 months. Leukopenia and agranulocytosis in combination with a typical bone marrow, exhibiting a complete arrest of myelopoiesis at the stage of promyelocytes led to the diagnosis of an antithyroid therapy induced agranulocytosis. After 1 week of antibiotic treatment without changes in neutrophil counts, granulocyte colony stimulating factor treatment at a dose of 300 micrograms/day subcutaneously was started. Twenty-four hours after the first administration the neutrophil counts began to rise, to 4389/microliters, with a maximum after the third administration and stabilizing at normal levels within 10 days. Since agranulocytosis is considered to be a severe and fatal complication of methimazole therapy, treatment with granulocyte colony stimulating factor seems to be useful for this life-threatening condition.</description><subject>Adult</subject><subject>Agranulocytosis - chemically induced</subject><subject>Agranulocytosis - complications</subject><subject>Agranulocytosis - pathology</subject><subject>Agranulocytosis - therapy</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - pathology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Granulocyte Colony-Stimulating Factor - therapeutic use</subject><subject>Graves Disease - complications</subject><subject>Graves Disease - drug therapy</subject><subject>Humans</subject><subject>Immunologic Factors - therapeutic use</subject><subject>Infection - etiology</subject><subject>Leukocyte Count - drug effects</subject><subject>Medical sciences</subject><subject>Methimazole - adverse effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: blood</subject><issn>0941-0198</issn><issn>1432-1440</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LwzAYxoMoc04v3oUcPAnVN2nSD29zOBUGXvRc0nxskbYpSYr0v7djY76X5_D8eOD9IXRL4JEA5E8vawDKaZGyMzQnLKUJYQzO0RxKRhIgZXGJrkL4AeA0z_kMzXJOKWTFHPXLrRfd0Dg5RhdswLZTg9QK1yMWXbRxN3pnFY477UU_4mesjdEyBuwMjl6L2Oou4t8JxP9LGkvXuG7EIdp2aES03RYbIaPz1-jCiCbom2Mu0Pf69Wv1nmw-3z5Wy00iU0JiUhY6y7jMqSJMiVKDMZlkJVEcqMrzQjBJspJTYyQ3VEAm6hp4phSvU1ILli7Qw2FXeheC16bqvW2FHysC1d5a9W9tgu8OcD_UrVYn9Khp6u-PvQhSNGZ6VNpwwtL9cUj_AD-odqc</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>ADORF, D</creator><creator>GRAJER, K. H</creator><creator>KABOTH, W</creator><creator>NERL, C</creator><general>Springer-Verlag</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19940501</creationdate><title>Agranulocytosis induced by antithyroid therapy : effects of treatment with granulocyte colony stimulating factor</title><author>ADORF, D ; GRAJER, K. H ; KABOTH, W ; NERL, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-98e665c72d14da9e0ff6c491d502d778a4c16952ffc5f2a06abb056dd5b31ba43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Agranulocytosis - chemically induced</topic><topic>Agranulocytosis - complications</topic><topic>Agranulocytosis - pathology</topic><topic>Agranulocytosis - therapy</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - pathology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Granulocyte Colony-Stimulating Factor - therapeutic use</topic><topic>Graves Disease - complications</topic><topic>Graves Disease - drug therapy</topic><topic>Humans</topic><topic>Immunologic Factors - therapeutic use</topic><topic>Infection - etiology</topic><topic>Leukocyte Count - drug effects</topic><topic>Medical sciences</topic><topic>Methimazole - adverse effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Toxicity: blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ADORF, D</creatorcontrib><creatorcontrib>GRAJER, K. H</creatorcontrib><creatorcontrib>KABOTH, W</creatorcontrib><creatorcontrib>NERL, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Clinical Investigator</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ADORF, D</au><au>GRAJER, K. 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After 1 week of antibiotic treatment without changes in neutrophil counts, granulocyte colony stimulating factor treatment at a dose of 300 micrograms/day subcutaneously was started. Twenty-four hours after the first administration the neutrophil counts began to rise, to 4389/microliters, with a maximum after the third administration and stabilizing at normal levels within 10 days. Since agranulocytosis is considered to be a severe and fatal complication of methimazole therapy, treatment with granulocyte colony stimulating factor seems to be useful for this life-threatening condition.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>7522068</pmid><doi>10.1007/BF00252834</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-0198 |
| ispartof | The Clinical Investigator, 1994-05, Vol.72 (5), p.390-392 |
| issn | 0941-0198 1432-1440 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Agranulocytosis - chemically induced Agranulocytosis - complications Agranulocytosis - pathology Agranulocytosis - therapy Biological and medical sciences Bone Marrow - pathology Drug toxicity and drugs side effects treatment Female Granulocyte Colony-Stimulating Factor - therapeutic use Graves Disease - complications Graves Disease - drug therapy Humans Immunologic Factors - therapeutic use Infection - etiology Leukocyte Count - drug effects Medical sciences Methimazole - adverse effects Pharmacology. Drug treatments Toxicity: blood |
| title | Agranulocytosis induced by antithyroid therapy : effects of treatment with granulocyte colony stimulating factor |
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