Potential radiopharmaceuticals for the detection of ocular melanoma. Part I. 5-iodo-2-thiouracil derivatives

The tissue distribution of a number of 5-[131I]-iodo-2-thiouracil derivatives was measured in Syrian golden hamsters with Greene melanoma. These compounds were rapidly (in less than 1 h) distributed in all tissues, while in most tissues fast elimination (T1/2 1-3 h) was observed. Because of retentio...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European Journal of Nuclear Medicine 1983-02, Vol.8 (2), p.45-51
Hauptverfasser:	van Langevelde, A, Bakker, C N, Broxterman, H J, Journée-de Korver, J G, Kaspersen, F M, Oosterhuis, J A, Pauwels, E K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cricetinae Eye Neoplasms - diagnostic imaging Iodine Radioisotopes Male Melanoma - diagnostic imaging Melanoma - metabolism Mesocricetus Neoplasm Transplantation Neoplasms, Experimental - metabolism Radionuclide Imaging Thiouracil - analogs & derivatives Thiouracil - metabolism Tissue Distribution
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The tissue distribution of a number of 5-[131I]-iodo-2-thiouracil derivatives was measured in Syrian golden hamsters with Greene melanoma. These compounds were rapidly (in less than 1 h) distributed in all tissues, while in most tissues fast elimination (T1/2 1-3 h) was observed. Because of retention of the 131I activity in the tumour, high tumour/non-tumour tissue ratios were found (e.g. tumour/eye 2.3-10, tumour/skin 1.5-3) suggesting that some of these compounds might be used as melanoma delineating agents, when labelled with 123I.
ISSN:	0340-6997 1619-7089
DOI:	10.1007/BF00252555