Experimental pancreas imaging study with 13N-glutamate using positron computer tomography
Accumulation of 13N-L-glutamate in the pancreas was experimentally evaluated by tissue distribution studies and by positron computer tomography imaging studies. The pancreas and salivary gland of Donryu rats exhibited a high rate of 13N-glutamate uptake. The percent administered dose/g of pancreas w...
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| Veröffentlicht in: | European Journal of Nuclear Medicine 1983, Vol.8 (12), p.528-530 |
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| container_title | European Journal of Nuclear Medicine |
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| creator | KUBOTA, K FUKUDA, H FUJIWARA, T SATO, T IWATA, R ITO, T YAMADA, K ENDO, S YAMMAURA, H MATSUZAWA, T ISHIWATA, K ITO, M ABE, Y YAMAGUCHI, T |
| description | Accumulation of 13N-L-glutamate in the pancreas was experimentally evaluated by tissue distribution studies and by positron computer tomography imaging studies. The pancreas and salivary gland of Donryu rats exhibited a high rate of 13N-glutamate uptake. The percent administered dose/g of pancreas was 3.8 at 20 min, 4.4 at 30 min after injection, and the pancreas to liver ratio was 1.9 and 2.5, respectively. The same results were obtained with Golden hamsters. The role of the feeding protocols was studied to optimize the technique. The fasting group showed a significantly higher uptake in the pancreas than in the free feeding group. The uptake in the fasting followed by a high protein meal group was higher than fasting only group, but the difference was not significant. Positron emission tomography of a miniature-pig with 13N-glutamate showed a clear image of the pancreas with the highest activity. It was concluded that 13N-glutamate was quite useful in positron imaging of the pancreas. |
| doi_str_mv | 10.1007/BF00251614 |
| format | Article |
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The pancreas and salivary gland of Donryu rats exhibited a high rate of 13N-glutamate uptake. The percent administered dose/g of pancreas was 3.8 at 20 min, 4.4 at 30 min after injection, and the pancreas to liver ratio was 1.9 and 2.5, respectively. The same results were obtained with Golden hamsters. The role of the feeding protocols was studied to optimize the technique. The fasting group showed a significantly higher uptake in the pancreas than in the free feeding group. The uptake in the fasting followed by a high protein meal group was higher than fasting only group, but the difference was not significant. Positron emission tomography of a miniature-pig with 13N-glutamate showed a clear image of the pancreas with the highest activity. It was concluded that 13N-glutamate was quite useful in positron imaging of the pancreas.</description><identifier>ISSN: 0340-6997</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/BF00251614</identifier><identifier>PMID: 6607837</identifier><identifier>CODEN: EJNMD9</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Cricetinae ; Digestive system. Abdomen ; Glutamates - chemical synthesis ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Mesocricetus ; Nitrogen Radioisotopes ; Pancreas - diagnostic imaging ; Rats ; Swine ; Swine, Miniature ; Tissue Distribution ; Tomography, Emission-Computed ; Ultrasonic investigative techniques</subject><ispartof>European Journal of Nuclear Medicine, 1983, Vol.8 (12), p.528-530</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1587-7900991f17a0083816ba18768f1ed252ce4a818287143daada6ca45e33001d2f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9378551$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6607837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUBOTA, K</creatorcontrib><creatorcontrib>FUKUDA, H</creatorcontrib><creatorcontrib>FUJIWARA, T</creatorcontrib><creatorcontrib>SATO, T</creatorcontrib><creatorcontrib>IWATA, R</creatorcontrib><creatorcontrib>ITO, T</creatorcontrib><creatorcontrib>YAMADA, K</creatorcontrib><creatorcontrib>ENDO, S</creatorcontrib><creatorcontrib>YAMMAURA, H</creatorcontrib><creatorcontrib>MATSUZAWA, T</creatorcontrib><creatorcontrib>ISHIWATA, K</creatorcontrib><creatorcontrib>ITO, M</creatorcontrib><creatorcontrib>ABE, Y</creatorcontrib><creatorcontrib>YAMAGUCHI, T</creatorcontrib><title>Experimental pancreas imaging study with 13N-glutamate using positron computer tomography</title><title>European Journal of Nuclear Medicine</title><addtitle>Eur J Nucl Med</addtitle><description>Accumulation of 13N-L-glutamate in the pancreas was experimentally evaluated by tissue distribution studies and by positron computer tomography imaging studies. The pancreas and salivary gland of Donryu rats exhibited a high rate of 13N-glutamate uptake. The percent administered dose/g of pancreas was 3.8 at 20 min, 4.4 at 30 min after injection, and the pancreas to liver ratio was 1.9 and 2.5, respectively. The same results were obtained with Golden hamsters. The role of the feeding protocols was studied to optimize the technique. The fasting group showed a significantly higher uptake in the pancreas than in the free feeding group. The uptake in the fasting followed by a high protein meal group was higher than fasting only group, but the difference was not significant. Positron emission tomography of a miniature-pig with 13N-glutamate showed a clear image of the pancreas with the highest activity. It was concluded that 13N-glutamate was quite useful in positron imaging of the pancreas.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cricetinae</subject><subject>Digestive system. Abdomen</subject><subject>Glutamates - chemical synthesis</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesocricetus</subject><subject>Nitrogen Radioisotopes</subject><subject>Pancreas - diagnostic imaging</subject><subject>Rats</subject><subject>Swine</subject><subject>Swine, Miniature</subject><subject>Tissue Distribution</subject><subject>Tomography, Emission-Computed</subject><subject>Ultrasonic investigative techniques</subject><issn>0340-6997</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAURS0EKqWwsCN5QAxIgec4ie0RqhaQKlhgYIpeHScNyhe2I-i_J1WjMt3hnneldwi5ZHDHAMT94xIgjFnCoiMyHUIFAqQ6JlPgEQSJUuKUnDn3BQBRxOMJmSQJCMnFlHwufjtjy9o0HivaYaOtQUfLGouyKajzfbalP6XfUMZfg6LqPdboDe3dru5aV3rbNlS3ddd7Y6lv67aw2G225-Qkx8qZizFn5GO5eJ8_B6u3p5f5wyrQLJYiEApAKZYzgQCSS5askUmRyJyZLIxDbSKUTIZSsIhniBkmGqPYcA7AsjDnM3Kz3-1s-90b59O6dNpUFTam7V0qYThVYTyAt3tQ29Y5a_K0Gx5Hu00ZpDuP6b_HAb4aV_t1bbIDOoob-uuxR6exyu1grnQHTHEh45jxP70zeZ4</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>KUBOTA, K</creator><creator>FUKUDA, H</creator><creator>FUJIWARA, T</creator><creator>SATO, T</creator><creator>IWATA, R</creator><creator>ITO, T</creator><creator>YAMADA, K</creator><creator>ENDO, S</creator><creator>YAMMAURA, H</creator><creator>MATSUZAWA, T</creator><creator>ISHIWATA, K</creator><creator>ITO, M</creator><creator>ABE, Y</creator><creator>YAMAGUCHI, T</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Experimental pancreas imaging study with 13N-glutamate using positron computer tomography</title><author>KUBOTA, K ; FUKUDA, H ; FUJIWARA, T ; SATO, T ; IWATA, R ; ITO, T ; YAMADA, K ; ENDO, S ; YAMMAURA, H ; MATSUZAWA, T ; ISHIWATA, K ; ITO, M ; ABE, Y ; YAMAGUCHI, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1587-7900991f17a0083816ba18768f1ed252ce4a818287143daada6ca45e33001d2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cricetinae</topic><topic>Digestive system. Abdomen</topic><topic>Glutamates - chemical synthesis</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesocricetus</topic><topic>Nitrogen Radioisotopes</topic><topic>Pancreas - diagnostic imaging</topic><topic>Rats</topic><topic>Swine</topic><topic>Swine, Miniature</topic><topic>Tissue Distribution</topic><topic>Tomography, Emission-Computed</topic><topic>Ultrasonic investigative techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUBOTA, K</creatorcontrib><creatorcontrib>FUKUDA, H</creatorcontrib><creatorcontrib>FUJIWARA, T</creatorcontrib><creatorcontrib>SATO, T</creatorcontrib><creatorcontrib>IWATA, R</creatorcontrib><creatorcontrib>ITO, T</creatorcontrib><creatorcontrib>YAMADA, K</creatorcontrib><creatorcontrib>ENDO, S</creatorcontrib><creatorcontrib>YAMMAURA, H</creatorcontrib><creatorcontrib>MATSUZAWA, T</creatorcontrib><creatorcontrib>ISHIWATA, K</creatorcontrib><creatorcontrib>ITO, M</creatorcontrib><creatorcontrib>ABE, Y</creatorcontrib><creatorcontrib>YAMAGUCHI, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European Journal of Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUBOTA, K</au><au>FUKUDA, H</au><au>FUJIWARA, T</au><au>SATO, T</au><au>IWATA, R</au><au>ITO, T</au><au>YAMADA, K</au><au>ENDO, S</au><au>YAMMAURA, H</au><au>MATSUZAWA, T</au><au>ISHIWATA, K</au><au>ITO, M</au><au>ABE, Y</au><au>YAMAGUCHI, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental pancreas imaging study with 13N-glutamate using positron computer tomography</atitle><jtitle>European Journal of Nuclear Medicine</jtitle><addtitle>Eur J Nucl Med</addtitle><date>1983</date><risdate>1983</risdate><volume>8</volume><issue>12</issue><spage>528</spage><epage>530</epage><pages>528-530</pages><issn>0340-6997</issn><eissn>1619-7089</eissn><coden>EJNMD9</coden><abstract>Accumulation of 13N-L-glutamate in the pancreas was experimentally evaluated by tissue distribution studies and by positron computer tomography imaging studies. The pancreas and salivary gland of Donryu rats exhibited a high rate of 13N-glutamate uptake. The percent administered dose/g of pancreas was 3.8 at 20 min, 4.4 at 30 min after injection, and the pancreas to liver ratio was 1.9 and 2.5, respectively. The same results were obtained with Golden hamsters. The role of the feeding protocols was studied to optimize the technique. The fasting group showed a significantly higher uptake in the pancreas than in the free feeding group. The uptake in the fasting followed by a high protein meal group was higher than fasting only group, but the difference was not significant. Positron emission tomography of a miniature-pig with 13N-glutamate showed a clear image of the pancreas with the highest activity. It was concluded that 13N-glutamate was quite useful in positron imaging of the pancreas.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>6607837</pmid><doi>10.1007/BF00251614</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biological and medical sciences Cricetinae Digestive system. Abdomen Glutamates - chemical synthesis Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Mesocricetus Nitrogen Radioisotopes Pancreas - diagnostic imaging Rats Swine Swine, Miniature Tissue Distribution Tomography, Emission-Computed Ultrasonic investigative techniques |
| title | Experimental pancreas imaging study with 13N-glutamate using positron computer tomography |
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