Silicone oil-induced hydrocephalus in the rabbit
Hydrocephalus was induced in adult rabbits by injecting silicone oil into the cisterna magna. Mean intracranial pressure was significantly elevated for approximately 36 h post-injection, during which time maximal ventricular dilatation was attained. Stretching and compression of periventricular tiss...
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| Veröffentlicht in: | Child's nervous system 1991-04, Vol.7 (2), p.79-84 |
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| creator | DEL BIGIO, M. R BRUNI, J. E |
| description | Hydrocephalus was induced in adult rabbits by injecting silicone oil into the cisterna magna. Mean intracranial pressure was significantly elevated for approximately 36 h post-injection, during which time maximal ventricular dilatation was attained. Stretching and compression of periventricular tissue and capillaries accompanied dilation of the lateral ventricles. Ventricular dilation promoted mitotic activity among the periventricular astroglia. Ventriculomegaly altered the metabolism of the monoamine neurotransmitters in the cortex, hippocampus, diencephalon, hypothalamus, and brain-stem. Ischemic injury to neurons of the hippocampal formation, particularly the dentate gyrus, was observed when hydrocephalus had persisted for more than 4 weeks. Cerebrospinal fluid shunting effectively reversed the neuropathologic changes only when done in the early stages of hydrocephalus. When hydrocephalus persisted for 8 weeks, rapid reversal of changes in the ependyma and periventricular capillaries was prevented largely by periventricular gliosis. |
| doi_str_mv | 10.1007/BF00247861 |
| format | Article |
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R ; BRUNI, J. E</creator><creatorcontrib>DEL BIGIO, M. R ; BRUNI, J. E</creatorcontrib><description>Hydrocephalus was induced in adult rabbits by injecting silicone oil into the cisterna magna. Mean intracranial pressure was significantly elevated for approximately 36 h post-injection, during which time maximal ventricular dilatation was attained. Stretching and compression of periventricular tissue and capillaries accompanied dilation of the lateral ventricles. Ventricular dilation promoted mitotic activity among the periventricular astroglia. Ventriculomegaly altered the metabolism of the monoamine neurotransmitters in the cortex, hippocampus, diencephalon, hypothalamus, and brain-stem. Ischemic injury to neurons of the hippocampal formation, particularly the dentate gyrus, was observed when hydrocephalus had persisted for more than 4 weeks. Cerebrospinal fluid shunting effectively reversed the neuropathologic changes only when done in the early stages of hydrocephalus. When hydrocephalus persisted for 8 weeks, rapid reversal of changes in the ependyma and periventricular capillaries was prevented largely by periventricular gliosis.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/BF00247861</identifier><identifier>PMID: 1677830</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Brain - metabolism ; Brain - pathology ; Cerebrospinal Fluid Shunts ; Hydrocephalus - chemically induced ; Hydrocephalus - metabolism ; Hydrocephalus - pathology ; Hydrocephalus - physiopathology ; Intracranial Pressure ; Male ; Medical sciences ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Neurotransmitter Agents - metabolism ; Rabbits ; Silicone Oils</subject><ispartof>Child's nervous system, 1991-04, Vol.7 (2), p.79-84</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-cde2ac89822c5023a7b6e7c7587fb2ca94d086e7320d95be28dd9590015f7b203</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4949346$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1677830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DEL BIGIO, M. R</creatorcontrib><creatorcontrib>BRUNI, J. E</creatorcontrib><title>Silicone oil-induced hydrocephalus in the rabbit</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><description>Hydrocephalus was induced in adult rabbits by injecting silicone oil into the cisterna magna. Mean intracranial pressure was significantly elevated for approximately 36 h post-injection, during which time maximal ventricular dilatation was attained. Stretching and compression of periventricular tissue and capillaries accompanied dilation of the lateral ventricles. Ventricular dilation promoted mitotic activity among the periventricular astroglia. Ventriculomegaly altered the metabolism of the monoamine neurotransmitters in the cortex, hippocampus, diencephalon, hypothalamus, and brain-stem. Ischemic injury to neurons of the hippocampal formation, particularly the dentate gyrus, was observed when hydrocephalus had persisted for more than 4 weeks. Cerebrospinal fluid shunting effectively reversed the neuropathologic changes only when done in the early stages of hydrocephalus. When hydrocephalus persisted for 8 weeks, rapid reversal of changes in the ependyma and periventricular capillaries was prevented largely by periventricular gliosis.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Cerebrospinal Fluid Shunts</subject><subject>Hydrocephalus - chemically induced</subject><subject>Hydrocephalus - metabolism</subject><subject>Hydrocephalus - pathology</subject><subject>Hydrocephalus - physiopathology</subject><subject>Intracranial Pressure</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>Rabbits</subject><subject>Silicone Oils</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj0tLw0AUhQdRaqxu3AtZuBJG7zySmVlqsSoUXKjrMK-QkTQpM8mi_96UFLs6cM_H4X4I3RJ4JADi6WUNQLmQJTlDGeGMYWAFnKMMaFFiARwu0VVKvwCkkFQt0IKUQkgGGYKv0Abbdz7vQ4tD50brXd7sXeyt3zW6HVMeunxofB61MWG4Rhe1bpO_OeYS_axfv1fvePP59rF63mDLCBmwdZ5qK5Wk1BZAmRam9MKKQoraUKsVdyCnC6PgVGE8lW5KdfiwFoYCW6KHedfGPqXo62oXw1bHfUWgOlhXJ-sJvpvh3Wi23p3QWXPq74-9Tla3ddSdDekf44orxkv2B2z0XOc</recordid><startdate>19910401</startdate><enddate>19910401</enddate><creator>DEL BIGIO, M. R</creator><creator>BRUNI, J. E</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19910401</creationdate><title>Silicone oil-induced hydrocephalus in the rabbit</title><author>DEL BIGIO, M. R ; BRUNI, J. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-cde2ac89822c5023a7b6e7c7587fb2ca94d086e7320d95be28dd9590015f7b203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Cerebrospinal Fluid Shunts</topic><topic>Hydrocephalus - chemically induced</topic><topic>Hydrocephalus - metabolism</topic><topic>Hydrocephalus - pathology</topic><topic>Hydrocephalus - physiopathology</topic><topic>Intracranial Pressure</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Neurotransmitter Agents - metabolism</topic><topic>Rabbits</topic><topic>Silicone Oils</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DEL BIGIO, M. R</creatorcontrib><creatorcontrib>BRUNI, J. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DEL BIGIO, M. R</au><au>BRUNI, J. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Silicone oil-induced hydrocephalus in the rabbit</atitle><jtitle>Child's nervous system</jtitle><addtitle>Childs Nerv Syst</addtitle><date>1991-04-01</date><risdate>1991</risdate><volume>7</volume><issue>2</issue><spage>79</spage><epage>84</epage><pages>79-84</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Hydrocephalus was induced in adult rabbits by injecting silicone oil into the cisterna magna. Mean intracranial pressure was significantly elevated for approximately 36 h post-injection, during which time maximal ventricular dilatation was attained. Stretching and compression of periventricular tissue and capillaries accompanied dilation of the lateral ventricles. Ventricular dilation promoted mitotic activity among the periventricular astroglia. Ventriculomegaly altered the metabolism of the monoamine neurotransmitters in the cortex, hippocampus, diencephalon, hypothalamus, and brain-stem. Ischemic injury to neurons of the hippocampal formation, particularly the dentate gyrus, was observed when hydrocephalus had persisted for more than 4 weeks. Cerebrospinal fluid shunting effectively reversed the neuropathologic changes only when done in the early stages of hydrocephalus. When hydrocephalus persisted for 8 weeks, rapid reversal of changes in the ependyma and periventricular capillaries was prevented largely by periventricular gliosis.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>1677830</pmid><doi>10.1007/BF00247861</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0256-7040 |
| ispartof | Child's nervous system, 1991-04, Vol.7 (2), p.79-84 |
| issn | 0256-7040 1433-0350 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00247861 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biological and medical sciences Brain - metabolism Brain - pathology Cerebrospinal Fluid Shunts Hydrocephalus - chemically induced Hydrocephalus - metabolism Hydrocephalus - pathology Hydrocephalus - physiopathology Intracranial Pressure Male Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Neurotransmitter Agents - metabolism Rabbits Silicone Oils |
| title | Silicone oil-induced hydrocephalus in the rabbit |
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