A study of the novel anti-inflammatory agent florifenine topical anti-inflammatory activity and influence on arachidonic acid metabolism and neutrophil functions

We have evaluated the effects of the novel anti-inflammatory agent florifenine, 2-(1-Pyrrolidinyl)ethyl N-[7-(trifluoromethyl)-4-quinolyl]anthranilate, on topical inflammation in mice, free radical-mediated reactions, arachidonic acid metabolism and some neutrophil functions. Topical administration...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 1995-03, Vol.351 (3), p.298
Hauptverfasser:	Bustos, G, Ferrándiz, M L, Sanz, M J, Payá, M, Alcaraz, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Aminoquinolines - pharmacology Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antioxidants - pharmacology Arachidonic Acid - metabolism Arachidonic Acid - pharmacology Cell Survival - drug effects Edema - drug therapy Eicosanoids - biosynthesis Free Radical Scavengers Humans Hydroxyl Radical - metabolism In Vitro Techniques Leukocyte Elastase Lipid Peroxidation - drug effects Mice Neutrophils - drug effects Neutrophils - enzymology Neutrophils - metabolism Pancreatic Elastase - metabolism Pyrrolidines - pharmacology Rats Superoxides - metabolism Tetradecanoylphorbol Acetate - pharmacology
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