The influence of the protector thiol L-cystein on the toxic and therapeutic responses of stabilized "activated" cyclophosphamide (4-(S-ethanol)-sulfido-cyclophosphamide)

The influence of L-cystein on the toxic and therapeutic responses of 4-(S-ethanol)-sulfido-cyclophosphamide (P1), a stabilized "activated" cyclophosphamide, was investigated. Stabilized "activated" cyclophosphamides hydrolyze under physiological conditions to 4-hydroxycyclophosph...

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Veröffentlicht in:	Investigational new drugs 1984-01, Vol.2 (2), p.253-259
Hauptverfasser:	Voelcker, G, Laber, P, Rockinger, H, Wientzek, C, Hohorst, H J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemotherapy, Cancer, Regional Perfusion Cyclophosphamide - administration & dosage Cyclophosphamide - analogs & derivatives Cyclophosphamide - therapeutic use Cyclophosphamide - toxicity Cysteine Female Humans Lethal Dose 50 Male Mice Mice, Nude Neoplasm Transplantation Rats Rats, Inbred Strains Sarcoma, Yoshida - drug therapy Structure-Activity Relationship Transplantation, Heterologous Urinary Bladder Neoplasms - drug therapy
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