Chemical characterization of ASTA Z 7557 (INN mafosfamide, CIS-4-sulfoethylthio-cyclophosphamide), a stable derivative of 4-hydroxy-cyclophosphamide

The primary metabolite of cyclophosphamide (CP, 1), i.e. 4-hydroxy-CP 2, has high pharmacological activity, but it is a very unstable compound. Chemical approaches to the stabilization involved in the substitution of the hydroxy group at the C 4-position, especially by a sulfoalkylthio-moiety. Withi...

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Veröffentlicht in:	Investigational new drugs 1984-06, Vol.2 (2), p.133-139
Hauptverfasser:	Niemeyer, U, Engel, J, Scheffler, G, Molge, K, Sauerbier, D, Weigert, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotransformation Cyclophosphamide - analogs & derivatives Cyclophosphamide - analysis Cyclophosphamide - chemical synthesis Cyclophosphamide - metabolism Hydrogen-Ion Concentration Hydrolysis Kinetics Stereoisomerism Temperature
Online-Zugang:	Volltext
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