Drug metabolism in rat colon: resolution of enzymatic constituents and characterization of activity

A direct demonstration of the basis of mixed function oxidase activity in rat colonic mucosa was achieved by resolution of microsomes into two components, cytochrome P-450 and cytochrome P-450 reductase, which on recombination with phosphatidylcholine catalyzed hydroxylation of benzo[alpha]pyrene an...

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Veröffentlicht in:	Molecular and cellular biochemistry 1987-05, Vol.75 (1), p.51-60
Hauptverfasser:	Oshinsky, R J, Strobel, H W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzo(a)pyrene - metabolism Benzphetamine - metabolism Colon - metabolism Cytochrome P-450 Enzyme System - metabolism Female In Vitro Techniques Intestinal Mucosa - metabolism Kinetics Microsomes - metabolism Mixed Function Oxygenases - metabolism NADPH-Ferrihemoprotein Reductase - metabolism Pharmaceutical Preparations - metabolism Rats
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