Affinity of chick microglia in vitro for ricin 120

Affinity of chick microglia in vitro for ricin 120

The distribution of binding sites for ricin 120 in cell cultures of spinal cord from the chick embryo was examined. A characteristic pattern was observed, which remained similar in cultures fixed by a variety of methods. Light microscopy demonstrated that the most prominent staining was of small rou...

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Veröffentlicht in:Cell and tissue research 1981, Vol.220 (2), p.313
Hauptverfasser: Debbage, P L, O'Dell, D S, James, D W
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cells, Cultured
Chick Embryo
Neuroglia - metabolism
Neuroglia - ultrastructure
Phagocytosis
Pseudopodia - ultrastructure
Ricin - metabolism
Spinal Cord
Staining and Labeling
Vacuoles - ultrastructure
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Zusammenfassung:The distribution of binding sites for ricin 120 in cell cultures of spinal cord from the chick embryo was examined. A characteristic pattern was observed, which remained similar in cultures fixed by a variety of methods. Light microscopy demonstrated that the most prominent staining was of small rounded or amoeboid cells. Electron microscopy showed that ricin was bound over their entire surfaces. The ultrastructural characteristics of these cells suggest their identification as microglia.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00210511