The metabolism of tramadol by human liver microsomes

The metabolism of tramadol was investigated in vitro using microsomal fractions of human liver. The parent compound and its main metabolites were determined by a newly developed high performance liquid chromatography assay. O-demethylation of tramadol was found to be stereoselective. The Vmax of the...

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Veröffentlicht in:	The Clinical Investigator 1992-08, Vol.70 (8), p.708-710
Hauptverfasser:	Paar, W D, Frankus, P, Dengler, H J
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans In Vitro Techniques Methylation Microsomes, Liver - metabolism Tramadol - metabolism
Online-Zugang:	Volltext
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