The selective dopamine D2 receptor antagonist raclopride discriminates between dopamine-mediated motor functions

The actions on central dopamine (DA) mechanisms of raclopride, a new substituted benzamide, were studied by means of behavioural and biochemical methods in the rat. Raclopride blocked the in vitro binding of the dopamine D2 antagonist 3H-spiperone (IC50 = 32 nM), but not of the unselective D1 antago...

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Veröffentlicht in:	Psychopharmacologia 1986-10, Vol.90 (3), p.287-294
Hauptverfasser:	OGREN, S. O, HALL, H, KOHLER, C, MAGNUSSON, O, SJOSTRAND, S.-E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals Apomorphine - pharmacology Applied sciences Behavior, Animal - drug effects Biological and medical sciences Catalepsy - chemically induced Catecholaminergic system Dopamine - physiology Emetics Exact sciences and technology Male Medical sciences Motor Activity - drug effects Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Other techniques and industries Pharmacology. Drug treatments Raclopride Rats Rats, Inbred Strains Receptors, Dopamine - drug effects Receptors, Dopamine D2 Salicylamides - pharmacology Stereotyped Behavior - drug effects
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