Systemic effects of different perfluorochemical agents
An intravitreal injection of Fluosol-DA leads to a higher alteration of the macrophage system of the retina than perfluorooctane and perfluorodecalin administered by the same route. The difference may be due to different kinds of oxidative damage caused by the three chemicals. To test the validity o...
Gespeichert in:
| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 1995, Vol.233 (1), p.48-51 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 51 |
|---|---|
| container_issue | 1 |
| container_start_page | 48 |
| container_title | Graefe's archive for clinical and experimental ophthalmology |
| container_volume | 233 |
| creator | AUGUSTIN, A. J SPITZNAS, M KOCH, F. H. J BÖKER, T MELLER, D LUTZ, J |
| description | An intravitreal injection of Fluosol-DA leads to a higher alteration of the macrophage system of the retina than perfluorooctane and perfluorodecalin administered by the same route. The difference may be due to different kinds of oxidative damage caused by the three chemicals. To test the validity of this assumption, the degree of cell alteration, expressed as reduction of cytoplasmic motility, caused by these three perfluorochemicals was examined.
Using the hepatic macrophage system of the rat, cell alteration was examined by magnetometry after intravenous application of various perfluorochemicals [emulsified perfluorodecalin (C10F18), perfluorooctane (C8F17Br) and Fluosol-DA (corresponding to a 20% emulsion of 70% perfluorodecalin and 30% perfluorotripropylamine, C9F21N)].
After administration of high doses, all perfluorochemicals led to cytoskeleton alteration. This alteration, expressed as retardation of the relaxation period of ferromagnetic iron oxide particles, was most pronounced after administration of Fluosol-DA.
The compromising effect of perfluorochemicals is dose dependent and differs among the three compounds tested, with Fluosol-DA showing the greatest decrease in cytoplasmic motility. |
| doi_str_mv | 10.1007/BF00177786 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF00177786</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>7721124</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-1d07c2fe515293a72ec44564b1f72754f056e477cf86f32a2acc350c473828823</originalsourceid><addsrcrecordid>eNpFjz1LA0EQQBdRYow29sIVVsLpzOzHXEoNRoWAhQrpjs1mV0-SXNi9FPn3bkiI1QzzHgNPiGuEewTgh6cxADJzZU5EH5XUJQNNT0UfmLCsJE3PxUVKvwCQIfZEjzNAUn1hPrap88vGFT4E77pUtKGYN3mPftUVax_DYtPG1v3sJLso7He-p0txFuwi-avDHIiv8fPn6LWcvL-8jR4npZOIXYlzYEfBa9Q0lJbJO6W0UTMMTKxVAG28YnahMkGSJeuc1OAUy4qqiuRA3O3_utimFH2o17FZ2ritEepde_3fnuWbvbzezJZ-flQPsZnfHrhNOSVEu3JNOmpSkdFmKP8AdytfNA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Systemic effects of different perfluorochemical agents</title><source>MEDLINE</source><source>SpringerLink Journals (MCLS)</source><creator>AUGUSTIN, A. J ; SPITZNAS, M ; KOCH, F. H. J ; BÖKER, T ; MELLER, D ; LUTZ, J</creator><creatorcontrib>AUGUSTIN, A. J ; SPITZNAS, M ; KOCH, F. H. J ; BÖKER, T ; MELLER, D ; LUTZ, J</creatorcontrib><description>An intravitreal injection of Fluosol-DA leads to a higher alteration of the macrophage system of the retina than perfluorooctane and perfluorodecalin administered by the same route. The difference may be due to different kinds of oxidative damage caused by the three chemicals. To test the validity of this assumption, the degree of cell alteration, expressed as reduction of cytoplasmic motility, caused by these three perfluorochemicals was examined.
Using the hepatic macrophage system of the rat, cell alteration was examined by magnetometry after intravenous application of various perfluorochemicals [emulsified perfluorodecalin (C10F18), perfluorooctane (C8F17Br) and Fluosol-DA (corresponding to a 20% emulsion of 70% perfluorodecalin and 30% perfluorotripropylamine, C9F21N)].
After administration of high doses, all perfluorochemicals led to cytoskeleton alteration. This alteration, expressed as retardation of the relaxation period of ferromagnetic iron oxide particles, was most pronounced after administration of Fluosol-DA.
The compromising effect of perfluorochemicals is dose dependent and differs among the three compounds tested, with Fluosol-DA showing the greatest decrease in cytoplasmic motility.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/BF00177786</identifier><identifier>PMID: 7721124</identifier><identifier>CODEN: GACODL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Cell Movement - drug effects ; Dose-Response Relationship, Drug ; Drug toxicity and drugs side effects treatment ; Electromagnetic Fields ; Emulsions ; Ferric Compounds ; Fluorocarbons - toxicity ; Injections, Intravenous ; Macrophages - drug effects ; Male ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Phagocytosis - drug effects ; Pharmacology. Drug treatments ; Random Allocation ; Rats ; Rats, Wistar</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 1995, Vol.233 (1), p.48-51</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-1d07c2fe515293a72ec44564b1f72754f056e477cf86f32a2acc350c473828823</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3426569$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7721124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AUGUSTIN, A. J</creatorcontrib><creatorcontrib>SPITZNAS, M</creatorcontrib><creatorcontrib>KOCH, F. H. J</creatorcontrib><creatorcontrib>BÖKER, T</creatorcontrib><creatorcontrib>MELLER, D</creatorcontrib><creatorcontrib>LUTZ, J</creatorcontrib><title>Systemic effects of different perfluorochemical agents</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>An intravitreal injection of Fluosol-DA leads to a higher alteration of the macrophage system of the retina than perfluorooctane and perfluorodecalin administered by the same route. The difference may be due to different kinds of oxidative damage caused by the three chemicals. To test the validity of this assumption, the degree of cell alteration, expressed as reduction of cytoplasmic motility, caused by these three perfluorochemicals was examined.
Using the hepatic macrophage system of the rat, cell alteration was examined by magnetometry after intravenous application of various perfluorochemicals [emulsified perfluorodecalin (C10F18), perfluorooctane (C8F17Br) and Fluosol-DA (corresponding to a 20% emulsion of 70% perfluorodecalin and 30% perfluorotripropylamine, C9F21N)].
After administration of high doses, all perfluorochemicals led to cytoskeleton alteration. This alteration, expressed as retardation of the relaxation period of ferromagnetic iron oxide particles, was most pronounced after administration of Fluosol-DA.
The compromising effect of perfluorochemicals is dose dependent and differs among the three compounds tested, with Fluosol-DA showing the greatest decrease in cytoplasmic motility.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Movement - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Electromagnetic Fields</subject><subject>Emulsions</subject><subject>Ferric Compounds</subject><subject>Fluorocarbons - toxicity</subject><subject>Injections, Intravenous</subject><subject>Macrophages - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Phagocytosis - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFjz1LA0EQQBdRYow29sIVVsLpzOzHXEoNRoWAhQrpjs1mV0-SXNi9FPn3bkiI1QzzHgNPiGuEewTgh6cxADJzZU5EH5XUJQNNT0UfmLCsJE3PxUVKvwCQIfZEjzNAUn1hPrap88vGFT4E77pUtKGYN3mPftUVax_DYtPG1v3sJLso7He-p0txFuwi-avDHIiv8fPn6LWcvL-8jR4npZOIXYlzYEfBa9Q0lJbJO6W0UTMMTKxVAG28YnahMkGSJeuc1OAUy4qqiuRA3O3_utimFH2o17FZ2ritEepde_3fnuWbvbzezJZ-flQPsZnfHrhNOSVEu3JNOmpSkdFmKP8AdytfNA</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>AUGUSTIN, A. J</creator><creator>SPITZNAS, M</creator><creator>KOCH, F. H. J</creator><creator>BÖKER, T</creator><creator>MELLER, D</creator><creator>LUTZ, J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1995</creationdate><title>Systemic effects of different perfluorochemical agents</title><author>AUGUSTIN, A. J ; SPITZNAS, M ; KOCH, F. H. J ; BÖKER, T ; MELLER, D ; LUTZ, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-1d07c2fe515293a72ec44564b1f72754f056e477cf86f32a2acc350c473828823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Movement - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Electromagnetic Fields</topic><topic>Emulsions</topic><topic>Ferric Compounds</topic><topic>Fluorocarbons - toxicity</topic><topic>Injections, Intravenous</topic><topic>Macrophages - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Phagocytosis - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AUGUSTIN, A. J</creatorcontrib><creatorcontrib>SPITZNAS, M</creatorcontrib><creatorcontrib>KOCH, F. H. J</creatorcontrib><creatorcontrib>BÖKER, T</creatorcontrib><creatorcontrib>MELLER, D</creatorcontrib><creatorcontrib>LUTZ, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AUGUSTIN, A. J</au><au>SPITZNAS, M</au><au>KOCH, F. H. J</au><au>BÖKER, T</au><au>MELLER, D</au><au>LUTZ, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic effects of different perfluorochemical agents</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>1995</date><risdate>1995</risdate><volume>233</volume><issue>1</issue><spage>48</spage><epage>51</epage><pages>48-51</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><coden>GACODL</coden><abstract>An intravitreal injection of Fluosol-DA leads to a higher alteration of the macrophage system of the retina than perfluorooctane and perfluorodecalin administered by the same route. The difference may be due to different kinds of oxidative damage caused by the three chemicals. To test the validity of this assumption, the degree of cell alteration, expressed as reduction of cytoplasmic motility, caused by these three perfluorochemicals was examined.
Using the hepatic macrophage system of the rat, cell alteration was examined by magnetometry after intravenous application of various perfluorochemicals [emulsified perfluorodecalin (C10F18), perfluorooctane (C8F17Br) and Fluosol-DA (corresponding to a 20% emulsion of 70% perfluorodecalin and 30% perfluorotripropylamine, C9F21N)].
After administration of high doses, all perfluorochemicals led to cytoskeleton alteration. This alteration, expressed as retardation of the relaxation period of ferromagnetic iron oxide particles, was most pronounced after administration of Fluosol-DA.
The compromising effect of perfluorochemicals is dose dependent and differs among the three compounds tested, with Fluosol-DA showing the greatest decrease in cytoplasmic motility.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>7721124</pmid><doi>10.1007/BF00177786</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 1995, Vol.233 (1), p.48-51 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00177786 |
| source | MEDLINE; SpringerLink Journals (MCLS) |
| subjects | Animals Biological and medical sciences Cell Movement - drug effects Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Electromagnetic Fields Emulsions Ferric Compounds Fluorocarbons - toxicity Injections, Intravenous Macrophages - drug effects Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Phagocytosis - drug effects Pharmacology. Drug treatments Random Allocation Rats Rats, Wistar |
| title | Systemic effects of different perfluorochemical agents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T06%3A44%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Systemic%20effects%20of%20different%20perfluorochemical%20agents&rft.jtitle=Graefe's%20archive%20for%20clinical%20and%20experimental%20ophthalmology&rft.au=AUGUSTIN,%20A.%20J&rft.date=1995&rft.volume=233&rft.issue=1&rft.spage=48&rft.epage=51&rft.pages=48-51&rft.issn=0721-832X&rft.eissn=1435-702X&rft.coden=GACODL&rft_id=info:doi/10.1007/BF00177786&rft_dat=%3Cpubmed_cross%3E7721124%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/7721124&rfr_iscdi=true |