Mechanism of irritant-induced cough: studies with a kinin antagonist and a kallikrein inhibitor

It has been suggested that bradykinin may play a role in stimulating cough in at least one pathological condition in humans. We have employed an animal model to investigate the possible role of this peptide in irritant-induced cough. The kinin antagonist Hoe 140 and codeine both produced dose-relate...

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Bibliographische Detailangaben
Veröffentlicht in:	Lung 1996, Vol.174 (4), p.269
Hauptverfasser:	Featherstone, R L, Parry, J E, Evans, D M, Jones, D M, Olsson, H, Szelke, M, Church, M K
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Bradykinin - administration & dosage Bradykinin - analogs & derivatives Bradykinin - pharmacology Bradykinin - physiology Bradykinin Receptor Antagonists Citric Acid - administration & dosage Codeine - pharmacology Codeine - therapeutic use Cough - chemically induced Cough - drug therapy Cough - physiopathology Dipeptides - pharmacology Dose-Response Relationship, Drug Glycopeptides - pharmacology Guinea Pigs Indomethacin - pharmacology Irritants - administration & dosage Kallikreins - antagonists & inhibitors Kinins - antagonists & inhibitors Male Protease Inhibitors - pharmacology
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