3-Deazauridine (NSC 126849): an interesting modulator of biochemical response

3-Deazauridine (NSC 126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog. Despite a paucity of clinical at...

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Veröffentlicht in:	Investigational new drugs 1986-01, Vol.4 (1), p.67-84
Hauptverfasser:	Moriconi, W J, Slavik, M, Taylor, S
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Deazauridine - metabolism 3-Deazauridine - pharmacology 3-Deazauridine - therapeutic use 3-Deazauridine - toxicity Acute Disease Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Azacitidine - analogs & derivatives Azacitidine - pharmacology Cytarabine - pharmacology Drug Evaluation Drug Synergism Galactosamine - pharmacology Humans Kinetics Leukemia - drug therapy Neoplasms - drug therapy Thymidine - pharmacology Uridine - analogs & derivatives
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