3-Deazauridine (NSC 126849): an interesting modulator of biochemical response
3-Deazauridine (NSC 126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog. Despite a paucity of clinical at...
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| Veröffentlicht in: | Investigational new drugs 1986-01, Vol.4 (1), p.67-84 |
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| creator | Moriconi, W J Slavik, M Taylor, S |
| description | 3-Deazauridine (NSC 126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with a number of antitumor agents including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine, although only the cytosine arabinoside/3-Deazauridine combination has been explored clinically. In this paper, the current status of the drug and future perspectives will be discussed. |
| doi_str_mv | 10.1007/BF00172020 |
| format | Article |
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Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with a number of antitumor agents including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine, although only the cytosine arabinoside/3-Deazauridine combination has been explored clinically. In this paper, the current status of the drug and future perspectives will be discussed.</description><subject>3-Deazauridine - metabolism</subject><subject>3-Deazauridine - pharmacology</subject><subject>3-Deazauridine - therapeutic use</subject><subject>3-Deazauridine - toxicity</subject><subject>Acute Disease</subject><subject>Animals</subject><subject>Antineoplastic Agents - metabolism</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Azacitidine - analogs & derivatives</subject><subject>Azacitidine - pharmacology</subject><subject>Cytarabine - pharmacology</subject><subject>Drug Evaluation</subject><subject>Drug Synergism</subject><subject>Galactosamine - pharmacology</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Leukemia - drug therapy</subject><subject>Neoplasms - drug therapy</subject><subject>Thymidine - pharmacology</subject><subject>Uridine - analogs & derivatives</subject><issn>0167-6997</issn><issn>1573-0646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0LFOwzAUhWELgUopLOxIHgEpcG0ndsxWCgWkAgPdo1vnGoyapLLTAZ6eolYwneXTGX7GTgVcCQBzfTsFEEaChD02FIVRGehc77MhCG0yba05ZEcpfQKAsiYfsIHMpRTKDNmzyu4Iv3EdQx1a4ucvbxMupC5ze3HDseWh7SlS6kP7zpuuXi-x7yLvPF-Ezn1QExwu-QasujbRMTvwuEx0stsRm0_v55PHbPb68DQZzzInS9lnVpHT3gmJwmuwhbU1LErUZH3hVAk5KmNJYlkIYXNVY4mkTe0JC1UQqhG73N662KUUyVerGBqMX5WA6rdI9V9kg8-2eLVeNFT_0V0C9QPICFlb</recordid><startdate>19860101</startdate><enddate>19860101</enddate><creator>Moriconi, W J</creator><creator>Slavik, M</creator><creator>Taylor, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19860101</creationdate><title>3-Deazauridine (NSC 126849): an interesting modulator of biochemical response</title><author>Moriconi, W J ; Slavik, M ; Taylor, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-93ec6fc12a1f609599d0b8a6e9f5c3804a379e2a8511943da8ae67dfea535ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>3-Deazauridine - metabolism</topic><topic>3-Deazauridine - pharmacology</topic><topic>3-Deazauridine - therapeutic use</topic><topic>3-Deazauridine - toxicity</topic><topic>Acute Disease</topic><topic>Animals</topic><topic>Antineoplastic Agents - metabolism</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Azacitidine - analogs & derivatives</topic><topic>Azacitidine - pharmacology</topic><topic>Cytarabine - pharmacology</topic><topic>Drug Evaluation</topic><topic>Drug Synergism</topic><topic>Galactosamine - pharmacology</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Leukemia - drug therapy</topic><topic>Neoplasms - drug therapy</topic><topic>Thymidine - pharmacology</topic><topic>Uridine - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moriconi, W J</creatorcontrib><creatorcontrib>Slavik, M</creatorcontrib><creatorcontrib>Taylor, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Investigational new drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moriconi, W J</au><au>Slavik, M</au><au>Taylor, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3-Deazauridine (NSC 126849): an interesting modulator of biochemical response</atitle><jtitle>Investigational new drugs</jtitle><addtitle>Invest New Drugs</addtitle><date>1986-01-01</date><risdate>1986</risdate><volume>4</volume><issue>1</issue><spage>67</spage><epage>84</epage><pages>67-84</pages><issn>0167-6997</issn><eissn>1573-0646</eissn><abstract>3-Deazauridine (NSC 126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with a number of antitumor agents including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine, although only the cytosine arabinoside/3-Deazauridine combination has been explored clinically. In this paper, the current status of the drug and future perspectives will be discussed.</abstract><cop>United States</cop><pmid>2422137</pmid><doi>10.1007/BF00172020</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0167-6997 |
| ispartof | Investigational new drugs, 1986-01, Vol.4 (1), p.67-84 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 3-Deazauridine - metabolism 3-Deazauridine - pharmacology 3-Deazauridine - therapeutic use 3-Deazauridine - toxicity Acute Disease Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Azacitidine - analogs & derivatives Azacitidine - pharmacology Cytarabine - pharmacology Drug Evaluation Drug Synergism Galactosamine - pharmacology Humans Kinetics Leukemia - drug therapy Neoplasms - drug therapy Thymidine - pharmacology Uridine - analogs & derivatives |
| title | 3-Deazauridine (NSC 126849): an interesting modulator of biochemical response |
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