Attempts to use the HPRT-assay as an automated short-term monitor for an acute exposure to mutagens

Attempts have been made to use the hypoxanthine-guanine-phospho-ribosyl-transferase-assay as a method for automated screening of agent-induced phenotypic variants of human peripheral lymphocytes reflecting 6-thioguanine resistance and assumed to indicate genotoxic action. Different protocols of the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell biology and toxicology 1992-10, Vol.8 (4), p.233-253
Hauptverfasser:	JOHANNISSON, A, ERIKSSON, B, AMNEUS, H, ZETTERBERG, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoradiography Biological and medical sciences Bromodeoxyuridine Cell Cycle - drug effects Cells, Cultured Chemical mutagenesis DNA - analysis Drug Resistance Ethyl Methanesulfonate - toxicity Flow Cytometry Humans Hypoxanthine Phosphoribosyltransferase - metabolism Lymphocyte Activation Lymphocytes - drug effects Male Medical sciences Microscopy, Fluorescence Mitomycin - toxicity Mutagenicity Tests Mutagens - toxicity Thioguanine - pharmacology Thiotepa - toxicity Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!