Relative cytotoxicity of psychotropic drugs in cultured rat hepatocytes

The relative cytotoxic effects of ten psychotropic drugs were assessed in rat hepatocyte monolayer cultures. Clear concentration-related toxicity was seen in the narrow range of 10(-5) M to 5 X 10(-5) M. The four cytotoxicity endpoints chosen were: release of the cytosolic enzyme, lactate dehydrogen...

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Veröffentlicht in:	Cell biology and toxicology 1987-09, Vol.3 (3), p.231-250
Hauptverfasser:	Boelsterli, U A, Bouis, P, Donatsch, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - metabolism Carbon Radioisotopes Cell Survival - drug effects Hemolysis - drug effects In Vitro Techniques L-Lactate Dehydrogenase - metabolism Liver - cytology Liver - metabolism Male Proteins - metabolism Psychotropic Drugs - metabolism Psychotropic Drugs - toxicity Rats Rats, Inbred Strains
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