HYALURONAN AND CELL LOCOMOTION
Hyaluronan (HA), a glycosaminoglycan, has long been implicated in cell locomotion. We have shown that HA production regulates the locomotion of H-ras-transformed cells. This autocrine motility mechanism is mediated by a novel HA receptor termed RHAMM, an acronym for Receptor for HA Mediated Motility...
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| Veröffentlicht in: | Cancer and metastasis reviews 1992-03, Vol.11 (1), p.21-30 |
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| container_title | Cancer and metastasis reviews |
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| creator | TURLEY, EA |
| description | Hyaluronan (HA), a glycosaminoglycan, has long been implicated in cell locomotion. We have shown that HA production regulates the locomotion of H-ras-transformed cells. This autocrine motility mechanism is mediated by a novel HA receptor termed RHAMM, an acronym for Receptor for HA Mediated Motility. HA: RHAMM interactions regulate directional locomotion of tumor cells and result in enhanced protein tyrosine phosphorylation that may be a critical messenger mechanism for initiation of locomotion. |
| doi_str_mv | 10.1007/BF00047600 |
| format | Article |
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We have shown that HA production regulates the locomotion of H-ras-transformed cells. This autocrine motility mechanism is mediated by a novel HA receptor termed RHAMM, an acronym for Receptor for HA Mediated Motility. HA: RHAMM interactions regulate directional locomotion of tumor cells and result in enhanced protein tyrosine phosphorylation that may be a critical messenger mechanism for initiation of locomotion.</description><subject>Animals</subject><subject>Cell Movement - physiology</subject><subject>Genes, ras - physiology</subject><subject>Humans</subject><subject>Hyaluronan Receptors</subject><subject>Hyaluronic Acid - physiology</subject><subject>Life Sciences & Biomedicine</subject><subject>Neoplasms - physiopathology</subject><subject>Oncology</subject><subject>Rats</subject><subject>Receptors, Cell Surface - physiology</subject><subject>Science & Technology</subject><subject>Wound Healing - physiology</subject><issn>0167-7659</issn><issn>1573-7233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkEFLw0AQhRdRaq1evCs9eVCis7tpZvcYY2sLMQFpD57CZjuBSNvUbIL4741E7NXTHN73PpjH2CWHew6AD48zAPAxADhiQz5B6aGQ8pgNgQfoYTDRp-zMufeOQol6wAZcKlBaDdn1_C2MV69pEibjMHkaR9M4HsdplL6ky0WanLOTwmwcXfzeEVvNpsto7sXp8yIKY88KJRpPUuBbnyygWUvSRnHUyEERB4lc5iRICNCkcJL7spAmV8qaoivnQAaEHLGb3ruvq4-WXJNtS2dpszE7qlqXoeQ-ooAOvO1BW1fO1VRk-7rcmvor45D9jJEdxujgq19rm29pfUD777tc9fkn5VXhbEk7S39UyLUW80TLTtXJorIxTVntoqrdNV317v9V-Q1eenUo</recordid><startdate>19920301</startdate><enddate>19920301</enddate><creator>TURLEY, EA</creator><general>Springer Nature</general><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920301</creationdate><title>HYALURONAN AND CELL LOCOMOTION</title><author>TURLEY, EA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-3e64c4ec07ad3e9a81797108e103713be2e2209e875b43f3ab88cafc28b0ea023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Cell Movement - physiology</topic><topic>Genes, ras - physiology</topic><topic>Humans</topic><topic>Hyaluronan Receptors</topic><topic>Hyaluronic Acid - physiology</topic><topic>Life Sciences & Biomedicine</topic><topic>Neoplasms - physiopathology</topic><topic>Oncology</topic><topic>Rats</topic><topic>Receptors, Cell Surface - physiology</topic><topic>Science & Technology</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TURLEY, EA</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer and metastasis reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TURLEY, EA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HYALURONAN AND CELL LOCOMOTION</atitle><jtitle>Cancer and metastasis reviews</jtitle><stitle>CANCER METAST REV</stitle><addtitle>Cancer Metastasis Rev</addtitle><date>1992-03-01</date><risdate>1992</risdate><volume>11</volume><issue>1</issue><spage>21</spage><epage>30</epage><pages>21-30</pages><issn>0167-7659</issn><eissn>1573-7233</eissn><abstract>Hyaluronan (HA), a glycosaminoglycan, has long been implicated in cell locomotion. 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| fulltext | fulltext |
| identifier | ISSN: 0167-7659 |
| ispartof | Cancer and metastasis reviews, 1992-03, Vol.11 (1), p.21-30 |
| issn | 0167-7659 1573-7233 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00047600 |
| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; SpringerNature Journals |
| subjects | Animals Cell Movement - physiology Genes, ras - physiology Humans Hyaluronan Receptors Hyaluronic Acid - physiology Life Sciences & Biomedicine Neoplasms - physiopathology Oncology Rats Receptors, Cell Surface - physiology Science & Technology Wound Healing - physiology |
| title | HYALURONAN AND CELL LOCOMOTION |
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