Persistent Depletion of I Kappa B Alpha and Interleukin-8 Expression in Human Pulmonary Epithelial Cells Exposed to Quartz Particles

Chronic inflammation and fibrosis following quartz inhalation has been associated with persistent up-regulation of several “pro-inflammatory” genes, which are commonly regulated by nuclear factor kappa-B (NF-κB). Transcription of the NF-κB-inhibitor IκBα is also under NF-κB control, and its de novo...

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Veröffentlicht in:	Toxicology and applied pharmacology 2000-09, Vol.167 (2), p.107-117
Hauptverfasser:	Schins, Roel P.F., McAlinden, Audrey, MacNee, William, Jimenez, L.Albert, Ross, James A., Guy, Keith, Faux, Stephen P., Donaldson, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Chemical and industrial products toxicology. Toxic occupational diseases Curcumin - pharmacology Cycloheximide - pharmacology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epithelial Cells - drug effects Epithelial Cells - metabolism Humans I-kappa B Proteins Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Interleukin-8 - genetics Interleukin-8 - metabolism Lung - cytology Lung - drug effects Lung - metabolism Medical sciences NF-kappa B - antagonists & inhibitors NF-KappaB Inhibitor alpha Proline - analogs & derivatives Proline - pharmacology Quartz - toxicity Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Thiocarbamates - pharmacology Titanium - toxicity Toxicology Tumor Cells, Cultured Up-Regulation
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