Selective Modulation of B-Cell Activation Markers CD86 and I-Ak on Murine Draining Lymph Node Cells Following Allergen or Irritant Treatment

It is well known that T cells are key effector cells in the development of allergic contact dermatitis. However, we and others have shown that mice exposed to contact allergens show a preferential increase in B lymphocytes in the draining lymph nodes (DLN) as seen by an increase in the percentage of...

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Veröffentlicht in:	Toxicology and applied pharmacology 1999-09, Vol.159 (2), p.142-151
Hauptverfasser:	Gerberick, G.Frank, Cruse, Lynn W., Miller, Cathy M., Ridder, Gregg M.
Format:	Artikel
Sprache:	eng
Schlagworte:	allergens Allergens - immunology Allergens - pharmacology Allergic diseases Animals Antibodies Antigens, CD - analysis B cells B-Lymphocytes - drug effects B7-2 Antigen Biological and medical sciences Biomarkers costimulatory molecules Dose-Response Relationship, Drug Ear, External - drug effects Female Flow Cytometry Histocompatibility Antigens Class II - analysis Immunoglobulin G - metabolism Immunoglobulin M - metabolism Immunoglobulins - metabolism Immunopathology irritants Irritants - immunology Irritants - pharmacology local lymph node assay Lymph Nodes - drug effects Lymphocyte Activation Medical sciences Membrane Glycoproteins - analysis MHC class II Mice Mice, Inbred CBA Skin allergic diseases. Stinging insect allergies T cells T-Lymphocytes - drug effects Time Factors
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