Tissue-Specific Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on the Activity of Phosphoenolpyruvate Carboxykinase (PEPCK) in Rats

Reduced gluconeogenesis due to decreased activity of key gluconeogenic enzymes in liver, together with feed refusal, has been suggested to play an important role in TCDD-induced lethality in rats. In this study the toxicological significance of reduced gluconeogenesis was further analyzed by studyin...

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Veröffentlicht in:	Toxicology and applied pharmacology 1995-12, Vol.135 (2), p.308-315
Hauptverfasser:	Viluksela, M., Stahl, B.U., Rozman, K.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - enzymology Animals Biological and medical sciences Blood Glucose Body Weight - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Dose-Response Relationship, Drug Kidney - drug effects Kidney - enzymology Kinetics Liver - drug effects Liver - enzymology Male Medical sciences Organ Specificity Phosphoenolpyruvate Carboxykinase (GTP) - metabolism Polychlorinated Dibenzodioxins - toxicity Rats Rats, Sprague-Dawley Toxicology Various organic compounds
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