Changes in Alveolar Lavage Materials and Lung Microsomal Xenobiotic Metabolism Following Exposures to HCl-Washed or Unwashed Crystalline Silica

Intratracheal exposures of rats to crystalline silica washed with HCl to remove iron contaminants have previously been shown to increase lung surfactant phospholipids (PL) and proteins and to alter the pulmonary microsomal cytochrome P450 system. We compared these effects of HCl-washed silica with t...

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Veröffentlicht in:	Toxicology and applied pharmacology 1994-12, Vol.129 (2), p.235-242
Hauptverfasser:	Miles, P.R., Bowman, L., Jones, W.G., Berry, D.S., Vallyathan, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Weight Bronchoalveolar Lavage Fluid - chemistry Chemical and industrial products toxicology. Toxic occupational diseases Electron Spin Resonance Spectroscopy Hydrochloric Acid Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Iron - isolation & purification Lung - drug effects Lung - metabolism Lung - physiology Male Medical sciences Microsomes - drug effects Microsomes - metabolism Organ Size Particle Size Phospholipids - metabolism Proteins - metabolism Rats Rats, Sprague-Dawley Silicon Dioxide - toxicity Toxicology Xenobiotics - metabolism
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