A Mechanistic Interpretation of the Oncogenicity of Chlorothalonil in Rodents and an Assessment of Human Relevance

Chronic dietary treatment of rodents with the fungicide chlorothalonil causes an increased incidence of papillomas and carcinomas of the forestomach squamous epithelium (rats and mice, both sexes) and adenomas and carcinomas of the renal proximal tubule epithelium (rats, both sexes; mice, males only...

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Veröffentlicht in:	Regulatory toxicology and pharmacology 1996-08, Vol.24 (1), p.69-84
Hauptverfasser:	Wilkinson, C.F., Killeen, J.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADMINISTRATION CENTRALE Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens CARCINOGENOS CARCINOGENS CENTRAL GOVERNMENT Chemical agents CHLOROTHALONIL CLOROTALONIL CYTOTOXICITY Dogs environmental protection agency ESTOMAC ESTOMAGO FARMACOLOGIA Female FORESTOMACH Fungicides, Industrial - adverse effects Fungicides, Industrial - toxicity GENERO HUMANO GENOTOXICITY GENRE HUMAIN GOBIERNO CENTRAL Guidelines as Topic Humans KIDNEYS Male MANKIND Medical sciences METABOLISM METABOLISME METABOLISMO Mice NEOPLASMAS NEOPLASME NEOPLASMS Neoplasms, Experimental - chemically induced Neoplasms, Experimental - epidemiology Nitriles - adverse effects Nitriles - metabolism Nitriles - toxicity nongenotoxic threshold mechanisms ONCOGENICIDAD ONCOGENICITE ONCOGENICITY PHARMACOLOGIE PHARMACOLOGY Rats REIN RIESGO RINONES RISK RISK ASSESSMENT RISQUE RODENTS ROEDORES RONGEUR Species Specificity STOMACH SUBSTANCE CANCERIGENE TOXICIDAD TOXICITE TOXICITY tumorigenicity Tumors United States United States Environmental Protection Agency
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