Effects of some medical drugs on enzyme activities of carbonic anhydrase from human erythrocytes in vitro and from rat erythrocytes in vivo

In this study, firstly, the effects of sodium ampicillin, magnesium sulfate, and sodium dipyrone on human carbonic anhydrase (HCA) (EC 4.2.1.1.) isozymes have been investigated in vitro. Human erythrocyte CA-I and CA-II isozymes were separately purified by affinity chromatography. Inhibition or acti...

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Veröffentlicht in:	Pharmacological research 2000-08, Vol.42 (2), p.187-191
Hauptverfasser:	Beydemir, Şükrü, Çİftçi, Mehmet, Özmen, İsmail, Okuroglu, Mehmet Emin Buyuk, Özdemir, Hasan, Küfrevioglu, ö.İrfan
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampicillin - pharmacology Animals Carbonic Anhydrase Inhibitors - pharmacology carbonic anhydrase, erythrocyte, medical drugs Carbonic Anhydrases - blood Carbonic Anhydrases - isolation & purification Dipyrone - pharmacology Dose-Response Relationship, Drug Erythrocytes - drug effects Erythrocytes - enzymology Humans Inhibitory Concentration 50 Isoenzymes - antagonists & inhibitors Isoenzymes - blood Isoenzymes - isolation & purification Magnesium Sulfate - pharmacology Rats
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